PMID- 28179312
OWN - NLM
STAT- MEDLINE
DCOM- 20170227
LR  - 20170227
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 2
DP  - 2017 Feb
TI  - MDS/AML del(11)(q14) Share Common Morphological Features Despite Different 
      Chromosomal Breakpoints.
PG  - 645-649
AB  - In myelodysplatic syndromes and acute myeloid leukemia (MDS/AML) deletion of the 
      11q14 region is a rare chromosomal defect (incidence: 0.6-1.0%), included within 
      the intermediate risk criteria by the International Prognostic Scoring System. No 
      fluorescence in situ hybridization (FISH) study has yet been performed to 
      identify a common breakpoint region (CBR). In our study through FISH with 
      bacterial artificial chromosomes and commercial probes, we analyzed seven 
      patients with MDS/AML harboring 11q14 deletion on conventional cytogenetic 
      analysis. FISH revealed deletions in five patients and amplifications in two. 
      Three patients with deletion carried a CBR, two had a deletion involving a more 
      centromeric breakpoint. These five patients exhibited multilineage dysplasia, 
      blast cells with large round nuclei, loose chromatin, small and abundant 
      nucleoli, and vacuolated cytoplasm with very thin Auer bodies. In conclusion, the 
      morphological features which occur independently of the extent of the deletion 
      are of multilineage dysplasia in MDS and leukemic blasts strongly reactive to 
      peroxidase in AML; despite the variable size of the deleted area, some patients 
      harbor a CBR.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Dambruoso, Irene
AU  - Dambruoso I
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy 
      i.dambruoso@smatteo.pv.it.
FAU - Invernizzi, Rosangela
AU  - Invernizzi R
AD  - Division of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, 
      Italy.
FAU - Boni, Marina
AU  - Boni M
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Zappatore, Rita
AU  - Zappatore R
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Giardini, Ilaria
AU  - Giardini I
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Cavigliano, Maria Paola
AU  - Cavigliano MP
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Rocca, Barbara
AU  - Rocca B
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Calvello, Celeste
AU  - Calvello C
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Bastia, Raffaella
AU  - Bastia R
AD  - Division of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, Pavia, 
      Italy.
FAU - Caresana, Marilena
AU  - Caresana M
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Pasi, Francesca
AU  - Pasi F
AD  - Division of Radiotherapy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
AD  - Laboratory of Neuro Radio Experimental Biology, Department of Biology and 
      Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
FAU - Nano, Rosanna
AU  - Nano R
AD  - Laboratory of Neuro Radio Experimental Biology, Department of Biology and 
      Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
FAU - Bernasconi, Paolo
AU  - Bernasconi P
AD  - Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - *Chromosome Breakpoints
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*genetics
OTO - NOTNLM
OT  - FISH
OT  - MDS/AML
OT  - chromosome 11
OT  - del(11)(q13-14)
OT  - deletion
OT  - morphology
EDAT- 2017/02/10 06:00
MHDA- 2017/02/28 06:00
CRDT- 2017/02/10 06:00
PHST- 2016/11/23 00:00 [received]
PHST- 2016/12/23 00:00 [revised]
PHST- 2017/01/09 00:00 [accepted]
PHST- 2017/02/10 06:00 [entrez]
PHST- 2017/02/10 06:00 [pubmed]
PHST- 2017/02/28 06:00 [medline]
AID - 37/2/645 [pii]
AID - 10.21873/anticanres.11359 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Feb;37(2):645-649. doi: 10.21873/anticanres.11359.