PMID- 28179599
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20170428
IS  - 1881-7823 (Electronic)
IS  - 1881-7815 (Linking)
VI  - 11
IP  - 1
DP  - 2017 Mar 22
TI  - The immune dysfunction in ankylosing spondylitis patients.
PG  - 69-76
LID - 10.5582/bst.2016.01171 [doi]
AB  - Ankylosing spondylitis (AS) is a spinal arthritic disease that is often 
      associated with human leukocyte antigen (HLA)-B27, while only part of HLA-B27 
      carriers become AS patients. T cells have been reported to play an important role 
      in the pathology of AS. T-cell immunoglobulin and mucin-domain-containing 
      molecule 3 (Tim-3) and programmed death-1 (PD-1) have been known to negatively 
      regulate the immune response. In this study, we used flow cytometry to analyze 
      the immunological differences of peripheral bloodfrom 21 patients with AS, 22 
      cases who didn't have AS but were found to be HLA-B27 positive (HLA-B27+ group), 
      and 16 normal healthy individuals (Healthy group). The level of CD4+, CD8+ T 
      cells,and Treg of each group was observed. The expression of Tim-3 and PD-1 and 
      the production of IFN-gamma, IL-6, TNF-alpha, IL-4, and IL-10 were examined as well. We 
      found that the percentage of Treg in AS group was lower than that of healthy 
      group. The expression of PD-1 on CD8+ T cells and Tim-3 on CD4+ T cells was lower 
      in the AS group. AS group had lower IL-10 production by CD4+ T cells and higher 
      IL-6 production by CD8+ T cells. The results of HLA-B27+ group were similar to 
      that of the healthy group. These data suggested that patients with AS had an 
      impairment in the ability to negatively regulate the immune response, which might 
      be related to the etiology of AS. To further investigate the roles of Tim-3 and 
      PD-1 on is a dysfunction of T cells in AS that is associated with PD-1 and Tim-3.
FAU - Duan, Zhongliang
AU  - Duan Z
AD  - Obstetrics and Gynecology Hospital, Fudan University.
FAU - Gui, Yuyan
AU  - Gui Y
FAU - Li, Cui
AU  - Li C
FAU - Lin, Jing
AU  - Lin J
FAU - Gober, Hans-Jurgen
AU  - Gober HJ
FAU - Qin, Juanxiu
AU  - Qin J
FAU - Li, Dajin
AU  - Li D
FAU - Wang, Ling
AU  - Wang L
LA  - eng
PT  - Journal Article
DEP - 20170207
PL  - Japan
TA  - Biosci Trends
JT  - Bioscience trends
JID - 101502754
RN  - 0 (HAVCR2 protein, human)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Hepatitis A Virus Cellular Receptor 2)
RN  - 0 (IL10 protein, human)
RN  - 0 (Interleukin-6)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Case-Control Studies
MH  - Female
MH  - HLA-B27 Antigen/immunology
MH  - Hepatitis A Virus Cellular Receptor 2/metabolism
MH  - Humans
MH  - Interleukin-10/metabolism
MH  - Interleukin-6/metabolism
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Signal Transduction
MH  - Spondylitis, Ankylosing/*immunology
MH  - T-Lymphocytes, Regulatory/immunology
MH  - Young Adult
EDAT- 2017/02/10 06:00
MHDA- 2017/04/30 06:00
CRDT- 2017/02/10 06:00
PHST- 2017/02/10 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
PHST- 2017/02/10 06:00 [entrez]
AID - 10.5582/bst.2016.01171 [doi]
PST - ppublish
SO  - Biosci Trends. 2017 Mar 22;11(1):69-76. doi: 10.5582/bst.2016.01171. Epub 2017 
      Feb 7.