PMID- 28179611
OWN - NLM
STAT- MEDLINE
DCOM- 20180228
LR  - 20180228
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 81
IP  - 5
DP  - 2017 Apr 25
TI  - Asymptomatic Cocaine Abuse　- Myocardial Tissue Characterization Using Cardiac 
      Biomarkers and Cardiovascular Magnetic Resonance Imaging.
PG  - 701-708
LID - 10.1253/circj.CJ-16-0941 [doi]
AB  - BACKGROUND: Use of cocaine is widespread and associated with several 
      cardiovascular diseases. Recent CMR studies indicate frequent myocardial 
      scar/fibrosis in asymptomatic cocaine abusers (CA).Methods and Results:This study 
      used a combination of advanced CMR tissue characterization techniques, including 
      late gadolinium enhancement (LGE) for focal, and extracellular volume (ECV) 
      imaging for diffuse myocardial injury/fibrosis, with circulating biomarkers for a 
      comprehensive characterization of myocardial injury. We included 20 cardiac 
      asymptomatic CA and a control group of 20 healthy volunteers. The comprehensive 
      assessment included physical examination, resting ECG, exercise ECG, cardiac 
      biomarkers, transthoracic echocardiogram and CMR. We did not find significant 
      differences between CA and controls either in functional CMR parameters such as 
      LVEDVi, LVESVi, LVEF, LV mass index, or in global myocardial ECV. Neither CA nor 
      controls had evidence of myocardial edema on T2-weighted CMR, but 8 CA (40%), and 
      none of the controls had focal myocardial scar (P<0.01). Interestingly, CA with 
      focal myocardial scar on LGE had significantly higher high-sensitivity troponin I 
      (hs-TNI) compared with CA without focal scar (median, 1.7 ng/L; IQR, 1.3-2.5 ng/L 
      vs. 0.6 ng/L; 0.4-1.3 ng/L; P<0.01). CONCLUSIONS: Focal myocardial injury in 
      terms of subtle LGE in 40% of asymptomatic CA was associated with higher hs-TNI. 
      Comprehensive assessment including advanced ECV imaging indicates a focal rather 
      than diffuse pattern of myocardial involvement in asymptomatic CA.
FAU - Radunski, Ulf K
AU  - Radunski UK
AD  - Department of General and Interventional Cardiology, University Heart Center 
      Hamburg.
FAU - Fuger, Ulrike
AU  - Fuger U
AD  - Department of Psychiatry and Psychotherapy, University Medical Center 
      Hamburg-Eppendorf.
FAU - Bohnen, Sebastian
AU  - Bohnen S
AD  - Department of General and Interventional Cardiology, University Heart Center 
      Hamburg.
FAU - Lund, Gunnar K
AU  - Lund GK
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Medical Center Hamburg-Eppendorf.
FAU - Stehning, Christian
AU  - Stehning C
AD  - Philips Research Germany.
FAU - Zeller, Tanja
AU  - Zeller T
AD  - Department of General and Interventional Cardiology, University Heart Center 
      Hamburg.
FAU - Tahir, Enver
AU  - Tahir E
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Medical Center Hamburg-Eppendorf.
FAU - Avanesov, Maxim
AU  - Avanesov M
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Medical Center Hamburg-Eppendorf.
FAU - Adam, Gerhard
AU  - Adam G
AD  - Department of Diagnostic and Interventional Radiology and Nuclear Medicine, 
      University Medical Center Hamburg-Eppendorf.
FAU - Blankenberg, Stefan
AU  - Blankenberg S
AD  - Department of General and Interventional Cardiology, University Heart Center 
      Hamburg.
FAU - Reimer, Jens
AU  - Reimer J
AD  - Center for Psychosocial Medicine, Health North.
AD  - Center for Interdisciplinary Addiction Medicine, University of Hamburg.
FAU - Muellerleile, Kai
AU  - Muellerleile K
AD  - Department of General and Interventional Cardiology, University Heart Center 
      Hamburg.
LA  - eng
PT  - Journal Article
DEP - 20170207
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Biomarkers)
RN  - 0 (Troponin I)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cardiomyopathies/*diagnosis/diagnostic imaging/pathology
MH  - Case-Control Studies
MH  - Cocaine-Related Disorders/*complications/pathology
MH  - Edema/diagnostic imaging/etiology
MH  - Female
MH  - Fibrosis/diagnostic imaging/etiology
MH  - Focal Adhesions
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Troponin I/blood
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - Cocaine abuse
OT  - Extracellular volume imaging
OT  - Myocardial tissue characterization
OT  - T1 mapping
EDAT- 2017/02/10 06:00
MHDA- 2018/03/01 06:00
CRDT- 2017/02/10 06:00
PHST- 2017/02/10 06:00 [pubmed]
PHST- 2018/03/01 06:00 [medline]
PHST- 2017/02/10 06:00 [entrez]
AID - 10.1253/circj.CJ-16-0941 [doi]
PST - ppublish
SO  - Circ J. 2017 Apr 25;81(5):701-708. doi: 10.1253/circj.CJ-16-0941. Epub 2017 Feb 
      7.