PMID- 28185008
OWN - NLM
STAT- MEDLINE
DCOM- 20170323
LR  - 20210212
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Print)
IS  - 1439-6319 (Linking)
VI  - 117
IP  - 3
DP  - 2017 Mar
TI  - Physical activity initiated by employer induces improvements in a novel set of 
      biomarkers of inflammation: an 8-week follow-up study.
PG  - 521-532
LID - 10.1007/s00421-016-3533-5 [doi]
AB  - PURPOSE: We investigated the level of pro- and anti-inflammatory biomarkers 
      before and after 8 weeks of unsupervised physical activity (PA) initiated by 
      employer. METHODS: During autumn 2014, background data, blood samples and 
      self-reported exercise level were collected from 76 men and 41 women in a 
      Norwegian road maintenance company. Monocyte chemoattractant protein-1 (MCP-1), 
      tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), leptin, adiponectin, 
      p-selectin and CD40 ligand (CD40L) were analyzed. [Formula: see text] was 
      measured in a subgroup of 50 subjects. RESULTS: With reference point of 
      exercise </=1 time/week, we found that participants who exercised 2-3 times/week 
      had higher [Formula: see text] values (5.6 mL kg(-1) min(-1); 95% CI [1.3, 9.9]). 
      MCP-1 was lower in those who exercised >/= 4 times/week (-81.98 pg/ml [-142.9, 
      -21.0]). IL-6 and p-selectin levels were lower in females who exercised >/=4 
      times/week (-1.04 pg/ml [-2.04, -0.03] and -13.75 ng/ml [-24.03, -3.48]). Leptin 
      was lower in participants who exercised 2-3 times/week (-0.39 microg/ml ln [-0.68, 
      -0.09]) and >/=4 times/week (-0.69 microg/ml ln [-1.10, -0.28]). During follow-up, 
      [Formula: see text] increased (2.9 mL kg(-1) min(-1) [1.5, 4.3]), while 
      p-selectin and CD40L decreased (-2.33 ng/ml [-3.78, -0.87] and 718.14 ng/ml 
      [-1368, -68]). MCP-1 levels decreased among men (-32.70 pg/ml [-51.21, -14.19]). 
      A joint analysis of all biomarkers (inversed adiponectin) showed that those who 
      exercised >/=4 times/week at baseline had lower total levels of biomarkers and that 
      total biomarker levels decreased during follow-up. CONCLUSIONS: Exercising 
      several times a week was associated with less inflammation compared to exercising 
      once a week or less. During the 8-week follow-up, total levels of biomarkers of 
      inflammation improved.
FAU - Lunde, Lars-Kristian
AU  - Lunde LK
AD  - Department of Work Psychology and Physiology, National Institute of Occupational 
      Health, Box 8149 Dep., 0033, Oslo, Norway.
FAU - Skare, Oivind
AU  - Skare O
AUID- ORCID: 0000-0001-8043-2820
AD  - Department of Occupational Medicine and Epidemiology, National Institute of 
      Occupational Health, Box 8149 Dep., 0033, Oslo, Norway. oivind.skare@stami.no.
FAU - Aass, Hans C D
AU  - Aass HCD
AD  - The Blood Cell Research Group, Section of Research, Department of Medical 
      Biochemistry, Oslo University Hospital, Ulleval, Norway.
FAU - Mamen, Asgeir
AU  - Mamen A
AD  - Norwegian School of Health Sciences, Kristiania University College, Box 1190 
      Sentrum, 0107, Oslo, Norway.
FAU - Einarsdottir, Elin
AU  - Einarsdottir E
AD  - Department of Chemical and Biological Work Environment, National Institute of 
      Occupational Health, Box 8149 Dep., 0033, Oslo, Norway.
FAU - Ulvestad, Bente
AU  - Ulvestad B
AD  - Department of Occupational Medicine and Epidemiology, National Institute of 
      Occupational Health, Box 8149 Dep., 0033, Oslo, Norway.
FAU - Skogstad, Marit
AU  - Skogstad M
AD  - Department of Occupational Medicine and Epidemiology, National Institute of 
      Occupational Health, Box 8149 Dep., 0033, Oslo, Norway.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170209
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Adipokines)
RN  - 0 (Biomarkers)
RN  - 0 (CD40 Antigens)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adipokines/*blood
MH  - Adult
MH  - Biomarkers/blood
MH  - CD40 Antigens/*blood
MH  - Cytokines/*blood
MH  - *Exercise
MH  - Female
MH  - Follow-Up Studies
MH  - Health Promotion/*methods
MH  - Humans
MH  - Inflammation/blood/prevention & control
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Workplace
PMC - PMC5346428
OTO - NOTNLM
OT  - Biomarkers of inflammation
OT  - Cardiovascular disease
OT  - Cytokines
OT  - Disease prevention
OT  - Health promotion
OT  - Physical activity
COIS- The authors declare that they have no conflict of interest.
EDAT- 2017/02/12 06:00
MHDA- 2017/03/24 06:00
PMCR- 2017/02/09
CRDT- 2017/02/11 06:00
PHST- 2016/05/27 00:00 [received]
PHST- 2016/12/30 00:00 [accepted]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2017/03/24 06:00 [medline]
PHST- 2017/02/11 06:00 [entrez]
PHST- 2017/02/09 00:00 [pmc-release]
AID - 10.1007/s00421-016-3533-5 [pii]
AID - 3533 [pii]
AID - 10.1007/s00421-016-3533-5 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2017 Mar;117(3):521-532. doi: 10.1007/s00421-016-3533-5. Epub 
      2017 Feb 9.