PMID- 28185621
OWN - NLM
STAT- MEDLINE
DCOM- 20170417
LR  - 20181202
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1488
DP  - 2017 Mar 10
TI  - An alternative perspective of hollow fiber-mediated extraction: Bundled hollow 
      fiber array-liquid-phase microextraction with sonication-assisted desorption and 
      liquid chromatography-tandem mass spectrometry for determination of estrogens in 
      aqueous matrices.
PG  - 26-36
LID - S0021-9673(17)30178-4 [pii]
LID - 10.1016/j.chroma.2017.01.081 [doi]
AB  - A bundled hollow fiber array (BHF)-liquid-phase microextraction (LPME) approach 
      has been developed for the ultra-high performance liquid chromatography tandem 
      mass spectrometric determination of estrone, 17beta-estradiol, estriol, and 
      17alpha-ethinylestradiol. The BHF was dipped in n-octanol to impregnate only the wall 
      pores of the hollow fibers without deliberate loading of extractant solvent in 
      the lumens, before placing it in the sample for extraction. Parameters 
      influencing extraction efficiency, such as number of bundled hollow fibers, type 
      of extraction and desorption solvent, agitation mode, extraction temperature and 
      duration, and the salting out effect were examined. Under the most favourable 
      experimental conditions, the enrichment factors were between 77 and 137-fold for 
      the target compounds. The developed method offered high sensitivity and 
      reproducibility. Low limits of detection and limits of quantification were 
      achieved, i.e., between 0.251 and 0.440ng/L, and 0.995 and 1.82ng/L, 
      respectively. Good intra and inter-day precision were obtained with relative 
      standard deviations (RSDs) of less than 9%. BHF-LPME provided a new perspective 
      on using membrane solvent-supported hollow fiber-mediated LPME. Raman 
      spectroscopy was also introduced in this study to reaffirm that the polypropylene 
      BHF did not play any role in the extraction; only the solvent was responsible.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Goh, Shalene Xue Lin
AU  - Goh SX
AD  - Department of Chemistry, National University of Singapore, 3 Science Drive 3, 
      Singapore 117543, Singapore; National University of Singapore Environmental 
      Research Institute, T-Lab Building #02-01, 5A Engineering Drive 1, Singapore 
      117411, Singapore.
FAU - Lee, Hian Kee
AU  - Lee HK
AD  - Department of Chemistry, National University of Singapore, 3 Science Drive 3, 
      Singapore 117543, Singapore; National University of Singapore Environmental 
      Research Institute, T-Lab Building #02-01, 5A Engineering Drive 1, Singapore 
      117411, Singapore. Electronic address: chmleehk@nus.edu.sg.
LA  - eng
PT  - Journal Article
DEP - 20170131
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Estrogens)
RN  - 0 (Solvents)
RN  - 0 (Water Pollutants, Chemical)
RN  - 059QF0KO0R (Water)
RN  - 2DI9HA706A (Estrone)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Chromatography, Liquid/*methods
MH  - Estradiol/analysis
MH  - Estrogens/*analysis/chemistry
MH  - Estrone/analysis/chemistry
MH  - Hydrogen-Ion Concentration
MH  - Limit of Detection
MH  - Liquid Phase Microextraction/*methods
MH  - Porosity
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Solvents/chemistry
MH  - Sonication/*methods
MH  - Spectrometry, Mass, Electrospray Ionization
MH  - Spectrum Analysis, Raman
MH  - Tandem Mass Spectrometry/*methods
MH  - Temperature
MH  - Water/*chemistry
MH  - Water Pollutants, Chemical/analysis
OTO - NOTNLM
OT  - Estrogens
OT  - Hollow fibers
OT  - Liquid-phase microextraction
OT  - Wastewater samples
EDAT- 2017/02/12 06:00
MHDA- 2017/04/18 06:00
CRDT- 2017/02/11 06:00
PHST- 2016/11/05 00:00 [received]
PHST- 2017/01/26 00:00 [revised]
PHST- 2017/01/27 00:00 [accepted]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2017/04/18 06:00 [medline]
PHST- 2017/02/11 06:00 [entrez]
AID - S0021-9673(17)30178-4 [pii]
AID - 10.1016/j.chroma.2017.01.081 [doi]
PST - ppublish
SO  - J Chromatogr A. 2017 Mar 10;1488:26-36. doi: 10.1016/j.chroma.2017.01.081. Epub 
      2017 Jan 31.