PMID- 28185865
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 78
IP  - 4
DP  - 2017 Apr
TI  - Cutaneous squamous cell cancer (cSCC) risk and the human leukocyte antigen (HLA) 
      system.
PG  - 327-335
LID - S0198-8859(17)30022-8 [pii]
LID - 10.1016/j.humimm.2017.02.002 [doi]
AB  - Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer among 
      Caucasians in the United States, with rising incidence over the past decade. 
      Treatment for non-melanoma skin cancer, including cSCC, in the United States was 
      estimated to cost $4.8 billion in 2014. Thus, an understanding of cSCC 
      pathogenesis could have important public health implications. Immune function 
      impacts cSCC risk, given that cSCC incidence rates are substantially higher in 
      patients with compromised immune systems. We report a systematic review of 
      published associations between cSCC risk and the human leukocyte antigen (HLA) 
      system. This review includes studies that analyze germline class I and class II 
      HLA allelic variation as well as HLA cell-surface protein expression levels 
      associated with cSCC risk. We propose biological mechanisms for these HLA-cSCC 
      associations based on known mechanisms of HLA involvement in other diseases. The 
      review suggests that immunity regulates the development of cSCC and that HLA-cSCC 
      associations differ between immunocompetent and immunosuppressed patients. This 
      difference may reflect the presence of viral co-factors that affect tumorigenesis 
      in immunosuppressed patients. Finally, we highlight limitations in the literature 
      on HLA-cSCC associations, and suggest directions for future research aimed at 
      understanding, preventing and treating cSCC.
CI  - Copyright (c) 2017 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Yesantharao, Pooja
AU  - Yesantharao P
AD  - Epidemiology Division, Department of Health Research & Policy, Stanford 
      University, Stanford, CA 94305, USA.
FAU - Wang, Wei
AU  - Wang W
AD  - Epidemiology Division, Department of Health Research & Policy, Stanford 
      University, Stanford, CA 94305, USA.
FAU - Ioannidis, Nilah M
AU  - Ioannidis NM
AD  - Epidemiology Division, Department of Health Research & Policy, Stanford 
      University, Stanford, CA 94305, USA.
FAU - Demehri, Shadmehr
AU  - Demehri S
AD  - Department of Dermatology, Massachusetts General Hospital, Harvard Medical 
      School, Boston, MA 02114, USA.
FAU - Whittemore, Alice S
AU  - Whittemore AS
AD  - Epidemiology Division, Department of Health Research & Policy, Stanford 
      University, Stanford, CA 94305, USA. Electronic address: alicesw@stanford.edu.
FAU - Asgari, Maryam M
AU  - Asgari MM
AD  - Department of Dermatology, Massachusetts General Hospital, Harvard Medical 
      School, Boston, MA 02114, USA.
LA  - eng
GR  - K24 AR069760/AR/NIAMS NIH HHS/United States
GR  - R01 CA166672/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20170207
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Carcinoma, Squamous Cell/*epidemiology/genetics/immunology
MH  - DNA Virus Infections/*epidemiology
MH  - Gene Frequency
MH  - Genome-Wide Association Study
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Immunity
MH  - Immunosuppression Therapy
MH  - Papillomaviridae/*physiology
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Skin Neoplasms/*epidemiology/genetics/immunology
MH  - United States
MH  - White People
PMC - PMC5428079
MID - NIHMS855751
OTO - NOTNLM
OT  - Cutaneous SCC
OT  - HLA
OT  - HPV
OT  - Immunosuppression
EDAT- 2017/02/12 06:00
MHDA- 2017/04/22 06:00
PMCR- 2018/04/01
CRDT- 2017/02/11 06:00
PHST- 2016/11/01 00:00 [received]
PHST- 2017/02/03 00:00 [revised]
PHST- 2017/02/03 00:00 [accepted]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
PHST- 2017/02/11 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - S0198-8859(17)30022-8 [pii]
AID - 10.1016/j.humimm.2017.02.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2017 Apr;78(4):327-335. doi: 10.1016/j.humimm.2017.02.002. Epub 2017 
      Feb 7.