PMID- 28186392
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20231112
IS  - 1939-005X (Electronic)
IS  - 1939-5094 (Print)
IS  - 1939-005X (Linking)
VI  - 9
IP  - 4
DP  - 2017 Jul
TI  - Understanding the mTOR signaling pathway via mathematical modeling.
LID - 10.1002/wsbm.1379 [doi]
LID - e1379
AB  - The mechanistic target of rapamycin (mTOR) is a central regulatory pathway that 
      integrates a variety of environmental cues to control cellular growth and 
      homeostasis by intricate molecular feedbacks. In spite of extensive knowledge 
      about its components, the molecular understanding of how these function together 
      in space and time remains poor and there is a need for Systems Biology approaches 
      to perform systematic analyses. In this work, we review the recent progress how 
      the combined efforts of mathematical models and quantitative experiments shed new 
      light on our understanding of the mTOR signaling pathway. In particular, we 
      discuss the modeling concepts applied in mTOR signaling, the role of multiple 
      feedbacks and the crosstalk mechanisms of mTOR with other signaling pathways. We 
      also discuss the contribution of principles from information and network theory 
      that have been successfully applied in dissecting design principles of the mTOR 
      signaling network. We finally propose to classify the mTOR models in terms of the 
      time scale and network complexity, and outline the importance of the 
      classification toward the development of highly comprehensive and predictive 
      models. WIREs Syst Biol Med 2017, 9:e1379. doi: 10.1002/wsbm.1379 For further 
      resources related to this article, please visit the WIREs website.
CI  - (c) 2017 The Authors. WIREs Systems Biology and Medicine published by Wiley 
      Periodicals, Inc.
FAU - Sulaimanov, Nurgazy
AU  - Sulaimanov N
AD  - Department of Electrical Engineering and Information Technology, Technische 
      Universitat Darmstadt, Darmstadt, Germany.
AD  - Department of Biology, Technische Universitat Darmstadt, Darmstadt, Germany.
FAU - Klose, Martin
AU  - Klose M
AD  - Systems Biology of the Cellular Microenvironment at the DKFZ Partner Site 
      Freiburg - Member of the German Cancer Consortium, Institute of Molecular 
      Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany 
      and German Cancer Research Center (DKFZ), Heidelberg, Germany.
FAU - Busch, Hauke
AU  - Busch H
AUID- ORCID: 0000-0003-4763-4521
AD  - Systems Biology of the Cellular Microenvironment at the DKFZ Partner Site 
      Freiburg - Member of the German Cancer Consortium, Institute of Molecular 
      Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany 
      and German Cancer Research Center (DKFZ), Heidelberg, Germany.
FAU - Boerries, Melanie
AU  - Boerries M
AD  - Systems Biology of the Cellular Microenvironment at the DKFZ Partner Site 
      Freiburg - Member of the German Cancer Consortium, Institute of Molecular 
      Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany 
      and German Cancer Research Center (DKFZ), Heidelberg, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170210
PL  - United States
TA  - Wiley Interdiscip Rev Syst Biol Med
JT  - Wiley interdisciplinary reviews. Systems biology and medicine
JID - 101516550
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Models, Biological
MH  - Signal Transduction/*physiology
MH  - Systems Biology/methods
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC5573916
EDAT- 2017/02/12 06:00
MHDA- 2018/02/13 06:00
PMCR- 2017/08/29
CRDT- 2017/02/11 06:00
PHST- 2016/07/01 00:00 [received]
PHST- 2016/11/09 00:00 [revised]
PHST- 2016/12/07 00:00 [accepted]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2017/02/11 06:00 [entrez]
PHST- 2017/08/29 00:00 [pmc-release]
AID - WSBM1379 [pii]
AID - 10.1002/wsbm.1379 [doi]
PST - ppublish
SO  - Wiley Interdiscip Rev Syst Biol Med. 2017 Jul;9(4):e1379. doi: 10.1002/wsbm.1379. 
      Epub 2017 Feb 10.