PMID- 28186516
OWN - NLM
STAT- MEDLINE
DCOM- 20170710
LR  - 20220409
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 8
IP  - 3
DP  - 2017 Mar 22
TI  - Apple and pear consumption and type 2 diabetes mellitus risk: a meta-analysis of 
      prospective cohort studies.
PG  - 927-934
LID - 10.1039/c6fo01378c [doi]
AB  - The conclusions from epidemiological studies are controversial between apple and 
      pear consumption and type 2 diabetes mellitus (T2DM) risk. The present study 
      aimed to investigate whether apple and pear consumption was inversely associated 
      with T2DM risk, and to evaluate the potential dose-response relationship. The 
      Cochrane library, Embase and PubMed databases were searched up to Nov 2016. 
      Prospective cohort studies, which reported the association of apple and pear 
      consumption with incidence of T2DM, were included. Multivariate-adjusted relative 
      risks (RRs) for the highest versus lowest category were combined by using a 
      random-effects model. A restricted cubic spline regression model was performed to 
      examine the dose-response relationship. A total of 5 independent prospective 
      cohort studies were included (14 120 T2DM incident cases and 228 315 
      participants). The summary estimate showed that consumption of apples and pears 
      was associated with 18% reduction in T2DM risk (95% confidence interval (CI): 
      0.75, 0.88; I(2) = 0.00%). Dose-response analysis showed that one serving per 
      week increment of apple and pear consumption was associated with a 3% (95% CI: 
      0.96, 0.98; p for trend <0.001) reduction in T2DM risk. The present meta-analysis 
      provides significant evidence of an inverse association between apple and pear 
      consumption and T2DM risk.
FAU - Guo, Xiao-Fei
AU  - Guo XF
AUID- ORCID: 0000-0003-0116-8609
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 
      duoli@zju.edu.cn.
FAU - Yang, Bo
AU  - Yang B
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 
      duoli@zju.edu.cn.
FAU - Tang, Jun
AU  - Tang J
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 
      duoli@zju.edu.cn.
FAU - Jiang, Jia-Jing
AU  - Jiang JJ
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 
      duoli@zju.edu.cn.
FAU - Li, Duo
AU  - Li D
AD  - Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China. 
      duoli@zju.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
SB  - IM
MH  - Diabetes Mellitus, Type 2/*diet therapy/epidemiology/metabolism
MH  - Humans
MH  - Malus/*metabolism
MH  - Prospective Studies
MH  - Pyrus/*metabolism
MH  - Risk Factors
EDAT- 2017/02/12 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/02/11 06:00
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
PHST- 2017/02/11 06:00 [entrez]
AID - 10.1039/c6fo01378c [doi]
PST - ppublish
SO  - Food Funct. 2017 Mar 22;8(3):927-934. doi: 10.1039/c6fo01378c.