PMID- 28186608
OWN - NLM
STAT- MEDLINE
DCOM- 20170629
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 34
IP  - 1
DP  - 2017 Feb 10
TI  - [Study of polymorphisms of HLA class Ⅰ (-A, -B, -C) and class Ⅱ (DRB1, DQA1, 
      DQB1, DPA1, DPB1) genes among ethnic Hans from Southern China].
PG  - 110-114
LID - 10.3760/cma.j.issn.1003-9406.2017.01.026 [doi]
AB  - OBJECTIVE: To study the genetic polymorphisms of human leukocyte antigen (HLA)- 
      A, B, C, DRB1, DQA1, DQB1, DPA1and DPB1among ethnic Hans from southern China. 
      METHODS: 481 randomly selected individuals were genotyped using a polymerase 
      chain reaction (PCR) sequence-based typing (SBT) method for the above genes. 
      Their allele frequencies were determined by direct counting. RESULTS: In total, 
      28 HLA-A, 57 HLA-B, 28 HLA-C, 40 HLA-DRB1, 18 HLA-DQA1, 17 HLA-DQB1, 6 
      HLA-DPA1and 21 HLA-DPB1alleles were identified. Among these, common alleles (with 
      allelic frequencies > 0.05) included A*1101, A*2402, A*0207, A*3303, A*0201, 
      B*40:01, B*46:01, B*58:01, B*13:01, B*15:02, C*01:02, C*07:02, C*03:04, C*03:02, 
      C*08:01, C*03:03, C*04:01, DRB1*09:01, DRB1*15:01, DRB1*12:02, DRB1*08:03, 
      DRB1*03:01, DRB1*04:05, DRB1*11:01, DQA1*01:02, DQA1*03:02, DQA1*03:03, 
      DQA1*06:01, DQA1*01:03, DQA1*05:05, DQA1*01:04, DQA1*03:01, DQA1*05:01, 
      DQB1*03:01, DQB1*03:03, DQB1*06:01, DQB1*05:02, DQB1*03:02, DQB1*02:01, 
      DQB1*03:02, DQB1*06:02, DPA1*02:02, DPA1*01:03, DPA1*02:01, DPB1*05:01, 
      DPB1*02:01, DPB1*13:01, DPB1*04:01and DPB1*02:02.For each of the locus, the 
      overall frequencies of common alleles were 75.57%, 52.81%, 78.28%, 62.16%, 
      86.70%, 77.23%, 95.32% and 81.59%, respectively. CONCLUSION: The allelic 
      frequencies of the 8 selected HLA loci among ethnic Hans from southern China may 
      served as a reference for anthropology, legal medicine, transplantation and 
      disease association studies.
FAU - Jin, Shizheng
AU  - Jin S
AD  - Shenzhen Blood Center, Shenzhen, Guangdong 518035, China. zhihui_deng@aliyun.com.
FAU - Zou, Hongyan
AU  - Zou H
FAU - Zhen, Jianxin
AU  - Zhen J
FAU - Wang, Daming
AU  - Wang D
FAU - He, Liumei
AU  - He L
FAU - Deng, Zhihui
AU  - Deng Z
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - China
MH  - Gene Frequency
MH  - Genotype
MH  - Genotyping Techniques/*methods
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DP Antigens/genetics
MH  - HLA-DQ alpha-Chains/genetics
MH  - HLA-DQ beta-Chains/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
EDAT- 2017/02/12 06:00
MHDA- 2017/07/01 06:00
CRDT- 2017/02/11 06:00
PHST- 2017/02/11 06:00 [entrez]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
AID - 940634026 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2017.01.026 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017 Feb 10;34(1):110-114. doi: 
      10.3760/cma.j.issn.1003-9406.2017.01.026.