PMID- 28187108 OWN - NLM STAT- MEDLINE DCOM- 20180306 LR - 20180413 IS - 1536-4828 (Electronic) IS - 0885-3177 (Linking) VI - 46 IP - 3 DP - 2017 Mar TI - Complicated Case Presentation: Management of Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1. PG - 416-426 LID - 10.1097/MPA.0000000000000770 [doi] AB - Multiple endocrine neoplasia type 1 (MEN1) is an inherited predisposition to tumors of the parathyroid glands, anterior pituitary, and pancreatic islet cells. In this review, we discuss the clinical case of a 45-year-old woman with MEN1 that was presented at the 2015 North American Neuroendocrine Tumor Society Symposium. In our review of this patient's complicated clinical course and subsequent operative management, we highlight controversies in the diagnosis and management of pancreatic neuroendocrine tumors in MEN1. In particular, this case illustrates the lack of consensus regarding the optimal biochemical and radiologic screening for pancreatic neuroendocrine tumors and absence of guidelines about the appropriate surgical approach for treatment. We review these controversies and discuss possible approaches to management. FAU - Mulvey, Claire K AU - Mulvey CK AD - From the *Department of Internal Medicine, daggerDivision of Hematology/Oncology, Department of Medicine, double daggerDivision of Endocrinology and Metabolism, Department of Medicine, and section signSection of Surgical Oncology/Hepatopancreaticobiliary Surgery, Division of General Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA. FAU - Van Loon, Katherine AU - Van Loon K FAU - Bergsland, Emily K AU - Bergsland EK FAU - Masharani, Umesh AU - Masharani U FAU - Nakakura, Eric K AU - Nakakura EK LA - eng PT - Case Reports PT - Journal Article PT - Review PL - United States TA - Pancreas JT - Pancreas JID - 8608542 SB - IM MH - Congresses as Topic MH - Female MH - Humans MH - Middle Aged MH - Multiple Endocrine Neoplasia Type 1/diagnosis/*therapy MH - Neuroendocrine Tumors/diagnosis/*therapy MH - Pancreatic Neoplasms/diagnosis/*therapy MH - Practice Guidelines as Topic EDAT- 2017/02/12 06:00 MHDA- 2018/03/07 06:00 CRDT- 2017/02/11 06:00 PHST- 2017/02/11 06:00 [entrez] PHST- 2017/02/12 06:00 [pubmed] PHST- 2018/03/07 06:00 [medline] AID - 00006676-201703000-00020 [pii] AID - 10.1097/MPA.0000000000000770 [doi] PST - ppublish SO - Pancreas. 2017 Mar;46(3):416-426. doi: 10.1097/MPA.0000000000000770.