PMID- 28188026
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20211204
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 44
IP  - 4
DP  - 2017 Aug
TI  - Clinical significance of integrin-linked kinase in laryngeal squamous cell 
      carcinoma.
PG  - 458-463
LID - S0385-8146(16)30364-9 [pii]
LID - 10.1016/j.anl.2016.09.002 [doi]
AB  - OBJECTIVE: To investigate the expression of integrin-linked kinase (ILK) and its 
      relationship with clinicopathological parameters in laryngeal squamous cell 
      carcinoma (LSCC). METHODS: 116 patients who had previously undergone complete 
      resection of tumor for LSCC were studied retrospectively. The level of ILK 
      expression in tumor tissues and adjacent nontumor tissues were determined by 
      immunohistochemistry. RESULTS: Increased expression of ILK was found in 65.5% of 
      cases. The expression of ILK protein was significantly associated with tumor 
      grade (p=0.046), lymph node metastasis (p=0.020), and pTNM stage (p=0.019). 
      Kaplan-Meier survival estimates showed a significant correlation between ILK 
      expression and patient survival rate (log-rank p<0.05). The multivariate survival 
      analysis revealed that N status was statistically significant prognostic factor 
      (p<0.001). Other parameters, such as ILK expression, cannot predict disease 
      prognosis separately. CONCLUSION: Increased expression of integrin-linked kinase 
      is associated with lymph node metastases and patient survival rate in laryngeal 
      squamous cell carcinoma. However, it does not appear to be an independent 
      prognostic predictor in LSCC.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Wu, Ping-An
AU  - Wu PA
AD  - Department of Otolaryngology, Head and Neck Surgery, The University of Hong 
      Kong-Shenzhen Hospital, Shenzhen 518053, Guangdong, PR China; Department of 
      Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South 
      University, Changsha 410011, Hunan, PR China.
FAU - Li, Shi-Sheng
AU  - Li SS
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, PR China.
FAU - Tang, Qing-Lai
AU  - Tang QL
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, PR China.
FAU - Liu, Bing-Bing
AU  - Liu BB
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, PR China.
FAU - Yang, Xin-Ming
AU  - Yang XM
AD  - Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, 
      Central South University, Changsha 410011, Hunan, PR China. Electronic address: 
      x16y2003@aliyun.com.
LA  - eng
PT  - Journal Article
DEP - 20170207
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - EC 2.7.1.- (integrin-linked kinase)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - Female
MH  - Head and Neck Neoplasms/*metabolism/mortality/pathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Lymph Nodes/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Survival Analysis
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - Integrin-linked kinase
OT  - Laryngeal carcinoma
OT  - Metastases
OT  - Prognosis
EDAT- 2017/02/12 06:00
MHDA- 2018/03/22 06:00
CRDT- 2017/02/12 06:00
PHST- 2015/11/02 00:00 [received]
PHST- 2016/07/05 00:00 [revised]
PHST- 2016/09/08 00:00 [accepted]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
PHST- 2017/02/12 06:00 [entrez]
AID - S0385-8146(16)30364-9 [pii]
AID - 10.1016/j.anl.2016.09.002 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2017 Aug;44(4):458-463. doi: 10.1016/j.anl.2016.09.002. Epub 
      2017 Feb 7.