PMID- 28188355
OWN - NLM
STAT- MEDLINE
DCOM- 20171201
LR  - 20190318
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 234
IP  - 7
DP  - 2017 Apr
TI  - Repeated MDMA administration increases MDMA-produced locomotor activity and 
      facilitates the acquisition of MDMA self-administration: role of dopamine D(2) 
      receptor mechanisms.
PG  - 1155-1164
LID - 10.1007/s00213-017-4554-4 [doi]
AB  - RATIONALE: Repeated exposure to +/-3, 4-methylenedioxymethamphetamine (MDMA) 
      produces sensitization to MDMA-produced hyperactivity, but the mechanisms 
      underlying the development of this sensitized response or the relationship to the 
      reinforcing effects of MDMA is unknown. OBJECTIVES: This study determined the 
      effect of a sensitizing regimen of MDMA exposure on the acquisition of MDMA 
      self-administration and investigated the role of dopamine D(2) receptor 
      mechanisms. METHODS: Rats received the selective D(2) antagonist, eticlopride 
      (0.0 or 0.3 mg/kg, i.p.) and MDMA (0.0 or 10.0 mg/kg, i.p.) during a five-day 
      pretreatment regimen. Two days following the final session, the locomotor 
      activating effects of MDMA (5 mg/kg, i.p.) and the latency to acquisition of MDMA 
      self-administration were determined. RESULTS: Pretreatment with MDMA enhanced the 
      locomotor activating effects of MDMA and facilitated the acquisition of MDMA 
      self-administration. Administration of eticlopride during MDMA pretreatment 
      completely blocked the development of sensitization to MDMA-produced 
      hyperactivity but failed to significantly alter the facilitated acquisition of 
      MDMA self-administration. Pretreatment with eticlopride alone facilitated the 
      acquisition of self-administration. CONCLUSIONS: These data suggest that repeated 
      MDMA exposure sensitized both the locomotor activating and reinforcing effects of 
      MDMA. Activation of D(2) receptors during MDMA pretreatment appears critical for 
      the development of sensitization to MDMA-produced hyperactivity. The role of D(2) 
      receptor mechanisms in the development of sensitization to the reinforcing 
      effects of MDMA is equivocal.
FAU - van de Wetering, Ross
AU  - van de Wetering R
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand.
FAU - Schenk, Susan
AU  - Schenk S
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand. susan.schenk@vuw.ac.nz.
LA  - eng
PT  - Journal Article
DEP - 20170210
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (DRD2 protein, rat)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Salicylamides)
RN  - 0 (Serotonin Agents)
RN  - J8M468HBH4 (eticlopride)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Dopamine Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Locomotion/drug effects
MH  - Male
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D2/*drug effects
MH  - Salicylamides/pharmacology
MH  - Self Administration
MH  - Serotonin Agents/*pharmacology
OTO - NOTNLM
OT  - *Dopamine receptor
OT  - *Eticlopride
OT  - *MDMA
OT  - *Self-administration
OT  - *Sensitization
EDAT- 2017/02/12 06:00
MHDA- 2017/12/02 06:00
CRDT- 2017/02/12 06:00
PHST- 2016/08/01 00:00 [received]
PHST- 2017/01/30 00:00 [accepted]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2017/12/02 06:00 [medline]
PHST- 2017/02/12 06:00 [entrez]
AID - 10.1007/s00213-017-4554-4 [pii]
AID - 10.1007/s00213-017-4554-4 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2017 Apr;234(7):1155-1164. doi: 
      10.1007/s00213-017-4554-4. Epub 2017 Feb 10.