PMID- 2818968
OWN - NLM
STAT- MEDLINE
DCOM- 19891227
LR  - 20190503
IS  - 0007-1072 (Print)
IS  - 0007-1072 (Linking)
VI  - 46
IP  - 6
DP  - 1989 Jun
TI  - Histocompatibility antigens in a population based silicosis series.
PG  - 364-9
AB  - Individual susceptibility to silicosis is suggested by the lack of a uniform dose 
      response relation and by the presence of immunological epiphenomena, such as 
      increased antibody levels and associated diseases that reflect altered immune 
      regulation. Human leucocyte antigens (HLA) are linked with immune response 
      capability and might indicate a possible genetic susceptibility to silicosis. 
      Forty nine silicotic subjects were identified from chest radiographs in a 
      population based study in Leadville, Colorado. They were interviewed for symptoms 
      and occupational history and gave a blood specimen for HLA-A, -B, -DR, and -DQ 
      typing and for antinuclear antibody, immune complexes, immunoglobulins, and 
      rheumatoid factor. Silicotic subjects had twice the prevalence of B44 (45%) of 
      the reference population and had triple the prevalence of A29 (20%), both of 
      which were statistically significant when corrected for the number of comparisons 
      made. No perturbations in D-region antigen frequencies were detected. 
      B44-positive subjects were older at diagnosis and had less dyspnoea than other 
      subjects. A29-positive subjects were more likely to have abnormal levels of IgA 
      and had higher levels of immune complexes. This study is the first to find 
      significant HLA antigen excesses among a series of silicotic cases and extends 
      earlier reported hypotheses that were based on groups of antigens of which B44 
      and A29 are components.
FAU - Kreiss, K
AU  - Kreiss K
AD  - National Jewish Center for Immunology and Respiratory Medicine, University of 
      Colorado School of Medicine, Denver.
FAU - Danilovs, J A
AU  - Danilovs JA
FAU - Newman, L S
AU  - Newman LS
LA  - eng
GR  - K01-OH00018/OH/NIOSH CDC HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Br J Ind Med
JT  - British journal of industrial medicine
JID - 0370637
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
CIN - Br J Ind Med. 1990 Jun;47(6):432. PMID: 2378823
MH  - Adult
MH  - Autoantibodies/analysis
MH  - Disease Susceptibility
MH  - HLA Antigens/*analysis
MH  - HLA-A Antigens/analysis
MH  - HLA-B Antigens/analysis
MH  - HLA-DQ Antigens/analysis
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Middle Aged
MH  - Silicosis/*immunology
PMC - PMC1009787
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
PMCR- 1989/06/01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
PHST- 1989/06/01 00:00 [pmc-release]
AID - 10.1136/oem.46.6.364 [doi]
PST - ppublish
SO  - Br J Ind Med. 1989 Jun;46(6):364-9. doi: 10.1136/oem.46.6.364.