PMID- 28191674
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20180731
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 26
IP  - 10
DP  - 2017 Oct
TI  - Induced histamine regulates Ni elution from an implanted Ni wire in mice by 
      downregulating neutrophil migration.
PG  - 868-874
LID - 10.1111/exd.13315 [doi]
AB  - Histamine regulates various inflammatory reactions. We have reported that the 
      expression of histidine decarboxylase (HDC) was induced by subcutaneous 
      implantation of nickel (Ni) wire. However, the source and functions of histamine 
      in Ni elution and Ni wire-induced inflammation have not been completely studied. 
      We aimed to elucidate the effects of de novo synthesized histamine on leucocyte 
      infiltration and Ni elution. Implantation of Ni wire induced an increase in the 
      Ni ion content of the surrounding tissues and serum and in the mRNA levels of 
      HDC, a histamine-producing enzyme, macrophage inflammatory protein-2 (MIP-2), a 
      chemoattractant for neutrophils, and monocyte chemoattractant protein-1 (MCP-1), 
      a chemoattractant for monocytes. The Ni wire induced HDC expression even in mast 
      cell-deficient WBB6F1-W/W(V) mice. In HDC knockout (HDC KO) mice, the Ni 
      wire-induced increase in MIP-2 mRNA expression was significantly higher than that 
      in wild-type mice but not MCP-1. MIP-2 expression was enhanced in histamine H2 
      receptor knockout (H2R KO) mice but not in WBB6F1-W/W(V) mice. Histamine 
      inhibited NiCl(2) -induced MIP-2 mRNA expression in mouse bone marrow-derived 
      macrophages (BMDMs) obtained from wild-type mice; this inhibition was not 
      observed in BMDMs from H2R KO mice. Ni elution increased in HDC KO mice, in which 
      leucocyte infiltration also increased, and was suppressed in mice treated with 
      neutrophil-specific antibody. These results suggest that the Ni wire induced HDC 
      expression in non-mast cells and that, in the chronic phase of inflammation, 
      endogenous histamine reduced Ni elution, probably through regulation of MIP-2 
      expression and neutrophil migration.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Kishimoto, Yu
AU  - Kishimoto Y
AUID- ORCID: 0000-0002-8876-0500
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
FAU - Asakawa, Sanki
AU  - Asakawa S
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
FAU - Sato, Taiki
AU  - Sato T
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
FAU - Takano, Takayuki
AU  - Takano T
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
FAU - Nakajyo, Takahisa
AU  - Nakajyo T
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
FAU - Mizuno, Natsumi
AU  - Mizuno N
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
FAU - Segawa, Ryosuke
AU  - Segawa R
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
FAU - Yoshikawa, Takeo
AU  - Yoshikawa T
AD  - Department of Pharmacology, Graduate School of Medicine, Tohoku University, 
      Sendai, Japan.
FAU - Hiratsuka, Masahiro
AU  - Hiratsuka M
AD  - Department of Pharmacology, Graduate School of Medicine, Tohoku University, 
      Sendai, Japan.
FAU - Yanai, Kazuhiko
AU  - Yanai K
AD  - Department of Pharmacology, Graduate School of Medicine, Tohoku University, 
      Sendai, Japan.
FAU - Ohtsu, Hiroshi
AU  - Ohtsu H
AD  - Department of Quantum Science and Energy Engineering, Graduate School of 
      Engineering, Tohoku University, Sendai, Japan.
FAU - Hirasawa, Noriyasu
AU  - Hirasawa N
AD  - Laboratory of Pharmacotherapy of Life-style Related Diseases, Graduate School of 
      Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170503
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL2)
RN  - 0 (Cxcl2 protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Histamine H2)
RN  - 696BNE976J (nickel chloride)
RN  - 7OV03QG267 (Nickel)
RN  - 820484N8I3 (Histamine)
RN  - EC 4.1.1.22 (Histidine Decarboxylase)
SB  - IM
MH  - Animals
MH  - *Cell Movement
MH  - Cells, Cultured
MH  - Chemokine CCL2/genetics/metabolism
MH  - Chemokine CXCL2/genetics/metabolism
MH  - Down-Regulation
MH  - Gene Expression/drug effects
MH  - Histamine/*metabolism/pharmacology
MH  - Histidine Decarboxylase/genetics/metabolism
MH  - Inflammation/etiology/genetics/*metabolism
MH  - Macrophages/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Neutrophils/*physiology
MH  - Nickel/adverse effects/*metabolism/pharmacology
MH  - Prostheses and Implants
MH  - RNA, Messenger/*metabolism
MH  - Receptors, Histamine H2/genetics
OTO - NOTNLM
OT  - H2 receptor
OT  - histidine decarboxylase
OT  - leukocyte
OT  - macrophage inflammatory protein-2
OT  - metal implant
EDAT- 2017/02/14 06:00
MHDA- 2018/07/19 06:00
CRDT- 2017/02/14 06:00
PHST- 2017/02/02 00:00 [accepted]
PHST- 2017/02/14 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2017/02/14 06:00 [entrez]
AID - 10.1111/exd.13315 [doi]
PST - ppublish
SO  - Exp Dermatol. 2017 Oct;26(10):868-874. doi: 10.1111/exd.13315. Epub 2017 May 3.