PMID- 28191680
OWN - NLM
STAT- MEDLINE
DCOM- 20180720
LR  - 20180816
IS  - 1600-0625 (Electronic)
IS  - 0906-6705 (Linking)
VI  - 26
IP  - 11
DP  - 2017 Nov
TI  - Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin 
      diseases.
PG  - 989-998
LID - 10.1111/exd.13314 [doi]
AB  - Host defense peptides/proteins (HDPs), also known as antimicrobial 
      peptides/proteins (AMPs), are key molecules in the cutaneous innate immune 
      system. AMPs/HDPs historically exhibit broad-spectrum killing activity against 
      bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs 
      were shown to have important biological functions, including inducing cell 
      proliferation, migration and differentiation; regulating inflammatory responses; 
      controlling the production of various cytokines/chemokines; promoting wound 
      healing; and improving skin barrier function. Despite the fact that AMPs/HDPs 
      protect our body, several studies have hypothesized that these molecules actively 
      contribute to the pathogenesis of various skin diseases. For example, AMPs/HDPs 
      play crucial roles in the pathological processes of psoriasis, atopic dermatitis, 
      rosacea, acne vulgaris, systemic lupus erythematosus and systemic sclerosis. 
      Thus, AMPs/HDPs may be a double-edged sword, promoting cutaneous immunity while 
      simultaneously initiating the pathogenesis of some skin disorders. This review 
      will describe the most common skin-derived AMPs/HDPs (defensins, cathelicidins, 
      S100 proteins, ribonucleases and dermcidin) and discuss the biology and both the 
      positive and negative aspects of these AMPs/HDPs in skin inflammatory/infectious 
      diseases. Understanding the regulation, functions and mechanisms of AMPs/HDPs may 
      offer new therapeutic opportunities in the treatment of various skin disorders.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Niyonsaba, Francois
AU  - Niyonsaba F
AUID- ORCID: 0000-0002-0588-8315
AD  - Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 
      Tokyo, Japan.
AD  - Faculty of International Liberal Arts, Juntendo University, Tokyo, Japan.
FAU - Kiatsurayanon, Chanisa
AU  - Kiatsurayanon C
AD  - Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 
      Tokyo, Japan.
AD  - Department of Dermatology and Allergology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
AD  - Department of Medical Services, Institute of Dermatology, Ministry of Public 
      Health, Bangkok, Thailand.
FAU - Chieosilapatham, Panjit
AU  - Chieosilapatham P
AD  - Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 
      Tokyo, Japan.
AD  - Department of Dermatology and Allergology, Juntendo University Graduate School of 
      Medicine, Tokyo, Japan.
FAU - Ogawa, Hideoki
AU  - Ogawa H
AD  - Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, 
      Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170427
PL  - Denmark
TA  - Exp Dermatol
JT  - Experimental dermatology
JID - 9301549
RN  - 0 (Antimicrobial Cationic Peptides)
RN  - 0 (Cathelicidins)
RN  - 0 (Defensins)
RN  - 0 (Peptides)
RN  - 0 (S100 Proteins)
RN  - 0 (dermcidin)
RN  - EC 3.1.- (Ribonucleases)
RN  - EC 3.1.27.- (Ribonuclease 7)
SB  - IM
MH  - Antimicrobial Cationic Peptides/*immunology/*metabolism
MH  - Cathelicidins/immunology/metabolism
MH  - Defensins/immunology/metabolism
MH  - Humans
MH  - Immunity, Innate
MH  - Peptides/immunology/metabolism
MH  - Ribonucleases/immunology/metabolism
MH  - S100 Proteins/immunology/metabolism
MH  - Skin/*immunology/*metabolism
MH  - Skin Diseases/*metabolism
MH  - Skin Physiological Phenomena
MH  - Wound Healing
OTO - NOTNLM
OT  - antimicrobial agent
OT  - infection
OT  - inflammation
OT  - skin immunity
OT  - therapeutic agent
EDAT- 2017/02/14 06:00
MHDA- 2018/07/22 06:00
CRDT- 2017/02/14 06:00
PHST- 2017/02/08 00:00 [accepted]
PHST- 2017/02/14 06:00 [pubmed]
PHST- 2018/07/22 06:00 [medline]
PHST- 2017/02/14 06:00 [entrez]
AID - 10.1111/exd.13314 [doi]
PST - ppublish
SO  - Exp Dermatol. 2017 Nov;26(11):989-998. doi: 10.1111/exd.13314. Epub 2017 Apr 27.