PMID- 28192672
OWN - NLM
STAT- MEDLINE
DCOM- 20180531
LR  - 20231112
IS  - 1520-5126 (Electronic)
IS  - 0002-7863 (Print)
IS  - 0002-7863 (Linking)
VI  - 139
IP  - 13
DP  - 2017 Apr 5
TI  - Smart Nanostructures for Cargo Delivery: Uncaging and Activating by Light.
PG  - 4584-4610
LID - 10.1021/jacs.6b08313 [doi]
AB  - Nanotechnology has begun to play a remarkable role in various fields of science 
      and technology. In biomedical applications, nanoparticles have opened new 
      horizons, especially for biosensing, targeted delivery of therapeutics, and so 
      forth. Among drug delivery systems (DDSs), smart nanocarriers that respond to 
      specific stimuli in their environment represent a growing field. Nanoplatforms 
      that can be activated by an external application of light can be used for a wide 
      variety of photoactivated therapies, especially light-triggered DDSs, relying on 
      photoisomerization, photo-cross-linking/un-cross-linking, photoreduction, and so 
      forth. In addition, light activation has potential in photodynamic therapy, 
      photothermal therapy, radiotherapy, protected delivery of bioactive moieties, 
      anticancer drug delivery systems, and theranostics (i.e., real-time monitoring 
      and tracking combined with a therapeutic action to different diseases sites and 
      organs). Combinations of these approaches can lead to enhanced and synergistic 
      therapies, employing light as a trigger or for activation. Nonlinear light 
      absorption mechanisms such as two-photon absorption and photon upconversion have 
      been employed in the design of light-responsive DDSs. The integration of a light 
      stimulus into dual/multiresponsive nanocarriers can provide spatiotemporal 
      controlled delivery and release of therapeutic agents, targeted and controlled 
      nanosystems, combined delivery of two or more agents, their on-demand release 
      under specific conditions, and so forth. Overall, light-activated nanomedicines 
      and DDSs are expected to provide more effective therapies against serious 
      diseases such as cancers, inflammation, infections, and cardiovascular disease 
      with reduced side effects and will open new doors toward the treatment of 
      patients worldwide.
FAU - Karimi, Mahdi
AU  - Karimi M
AUID- ORCID: 0000-0002-7977-3940
AD  - Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical 
      School , Boston, Massachusetts 02114, United States.
FAU - Sahandi Zangabad, Parham
AU  - Sahandi Zangabad P
AUID- ORCID: 0000-0001-8316-6732
AD  - Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of 
      Medical Science (TUOMS) , Tabriz, Iran.
AD  - Department of Materials Science and Engineering, Sharif University of Technology 
      , 11365-9466 Tehran, Iran.
AD  - Nanomedicine Research Association (NRA), Universal Scientific Education and 
      Research Network (USERN) , Tehran, Iran.
FAU - Baghaee-Ravari, Soodeh
AU  - Baghaee-Ravari S
AD  - Joint School of Nanoscience and Nanoengineering, University of North Carolina at 
      Greensboro , Greensboro, North Carolina 27401, United States.
FAU - Ghazadeh, Mehdi
AU  - Ghazadeh M
AD  - Joint School of Nanoscience and Nanoengineering, University of North Carolina at 
      Greensboro , Greensboro, North Carolina 27401, United States.
FAU - Mirshekari, Hamid
AU  - Mirshekari H
FAU - Hamblin, Michael R
AU  - Hamblin MR
AUID- ORCID: 0000-0001-6431-4605
AD  - Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical 
      School , Boston, Massachusetts 02114, United States.
AD  - Department of Dermatology, Harvard Medical School , Boston, Massachusetts 02115, 
      United States.
AD  - Harvard-MIT Division of Health Sciences and Technology , Cambridge, Massachusetts 
      02139, United States.
LA  - eng
GR  - R01 AI050875/AI/NIAID NIH HHS/United States
GR  - R21 AI121700/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20170313
PL  - United States
TA  - J Am Chem Soc
JT  - Journal of the American Chemical Society
JID - 7503056
RN  - 0 (Drug Carriers)
SB  - IM
MH  - Animals
MH  - Drug Carriers/*chemistry/*radiation effects
MH  - Humans
MH  - *Light
MH  - Nanomedicine
MH  - Nanostructures/*chemistry/*radiation effects
MH  - Neoplasms/*drug therapy
MH  - *Photochemotherapy
PMC - PMC5475407
MID - NIHMS865683
COIS- Notes The authors declare no competing financial interest.
EDAT- 2017/02/14 06:00
MHDA- 2018/06/01 06:00
PMCR- 2018/04/05
CRDT- 2017/02/14 06:00
PHST- 2017/02/14 06:00 [pubmed]
PHST- 2018/06/01 06:00 [medline]
PHST- 2017/02/14 06:00 [entrez]
PHST- 2018/04/05 00:00 [pmc-release]
AID - 10.1021/jacs.6b08313 [doi]
PST - ppublish
SO  - J Am Chem Soc. 2017 Apr 5;139(13):4584-4610. doi: 10.1021/jacs.6b08313. Epub 2017 
      Mar 13.