PMID- 28193293
OWN - NLM
STAT- MEDLINE
DCOM- 20170222
LR  - 20181113
IS  - 1746-1596 (Electronic)
IS  - 1746-1596 (Linking)
VI  - 12
IP  - 1
DP  - 2017 Feb 13
TI  - Loss of chromosome 13 material in cellular angiofibromas indicates pathogenetic 
      similarity with spindle cell lipomas.
PG  - 17
LID - 10.1186/s13000-017-0607-6 [doi]
LID - 17
AB  - BACKGROUND: Cellular angiofibroma is a rare benign mesenchymal neoplasm with 
      morphological and immunohistochemical similarities to spindle cell lipoma. 
      Karyotypic information on cellular angiofibroma is restricted to one case only 
      which showed loss of material from chromosomes 13 and 16. A few other studies 
      using fluorescence in situ hybridization showed deletions of the RB1 and FOXO1 
      loci, both of which are located in chromosome band 13q14. We present here 
      cytogenetic data on two cellular angiofibromas with an abnormal karyotype. 
      METHODS: G-banding and fluorescence in situ hybridization (FISH) analyses were 
      done on two cellular angiofibromas. RESULTS: In both tumors, a rearrangement 
      leading to loss of chromosome 13 material was seen, together with other 
      structural chromosome abnormalities. FISH analysis showed heterozygous deletion 
      of the RB1 locus (13q14) in both cases. CONCLUSION: Our results demonstrate loss 
      of chromosome 13 material in cellular angiofibroma, though not as the sole 
      cytogenetic change, confirming the (cyto)genetic similarity of these tumors with 
      spindle cell lipomas.
FAU - Panagopoulos, Ioannis
AU  - Panagopoulos I
AUID- ORCID: 0000-0003-2159-5341
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, P.O.Box 4953, Nydalen, 
      NO-0424, Oslo, Norway. ioannis.panagopoulos@rr-research.no.
FAU - Gorunova, Ludmila
AU  - Gorunova L
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, P.O.Box 4953, Nydalen, 
      NO-0424, Oslo, Norway.
FAU - Bjerkehagen, Bodil
AU  - Bjerkehagen B
AD  - Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 
      Oslo, Norway.
FAU - Andersen, Kristin
AU  - Andersen K
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, P.O.Box 4953, Nydalen, 
      NO-0424, Oslo, Norway.
FAU - Lund-Iversen, Marius
AU  - Lund-Iversen M
AD  - Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, 
      Oslo, Norway.
FAU - Heim, Sverre
AU  - Heim S
AD  - Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, 
      The Norwegian Radium Hospital, Oslo University Hospital, P.O.Box 4953, Nydalen, 
      NO-0424, Oslo, Norway.
AD  - Faculty of Medicine, University of Oslo, Oslo, Norway.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170213
PL  - England
TA  - Diagn Pathol
JT  - Diagnostic pathology
JID - 101251558
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Aged
MH  - Angiofibroma/diagnosis/*genetics/pathology
MH  - Biomarkers, Tumor/analysis
MH  - Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Karyotyping/methods
MH  - Lipoma/diagnosis/*pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Muscle Tissue/diagnosis/*genetics/pathology
MH  - Retinoblastoma Protein/*genetics
PMC - PMC5307663
OTO - NOTNLM
OT  - Cellular angiofibroma
OT  - Chromosome 13
OT  - Cytogenetics
OT  - Spindle cell lipoma
EDAT- 2017/02/15 06:00
MHDA- 2017/02/23 06:00
PMCR- 2017/02/13
CRDT- 2017/02/15 06:00
PHST- 2016/11/11 00:00 [received]
PHST- 2017/01/31 00:00 [accepted]
PHST- 2017/02/15 06:00 [entrez]
PHST- 2017/02/15 06:00 [pubmed]
PHST- 2017/02/23 06:00 [medline]
PHST- 2017/02/13 00:00 [pmc-release]
AID - 10.1186/s13000-017-0607-6 [pii]
AID - 607 [pii]
AID - 10.1186/s13000-017-0607-6 [doi]
PST - epublish
SO  - Diagn Pathol. 2017 Feb 13;12(1):17. doi: 10.1186/s13000-017-0607-6.