PMID- 28194699
OWN - NLM
STAT- MEDLINE
DCOM- 20180323
LR  - 20181113
IS  - 0973-7693 (Electronic)
IS  - 0019-5456 (Linking)
VI  - 84
IP  - 6
DP  - 2017 Jun
TI  - Efficacy and Safety of 2% Topical Propranolol Cream for the Treatment of 
      Proliferating Infantile Strawberry Hemangiomas.
PG  - 425-429
LID - 10.1007/s12098-017-2303-7 [doi]
AB  - OBJECTIVE: To evaluate the efficacy and safety of 2% topical propranolol cream in 
      the treatment of proliferating infantile strawberry hemangiomas. METHODS: A total 
      of 40 infants were enrolled; 2% propranolol cream was applied three times daily. 
      In the subsequent monthly visit, dynamic changes in tumor size, texture, and 
      color were recorded. The adverse events (AEs) were observed. Treatment outcomes 
      were scored on a four-point scale. All patients were followed up for 12 mo after 
      treatment. RESULTS: The overall response was graded Scale 1 (poor response) in 2 
      patients, Scale 2 (moderate response) in 15 patients, Scale 3 (good response) in 
      17 patients, and Scale 4 (excellent response) in 6 patients. No significant 
      differences were seen in treatment outcomes between female and male patients, 
      among lesion locations/size, or in the age at the start of the treatment. No 
      obvious AEs were reported. CONCLUSIONS: 2% topical propranolol cream is safe and 
      effective for the treatment of proliferating infantile strawberry hemangiomas.
FAU - Wang, Yuanyuan
AU  - Wang Y
AD  - Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of 
      Surgery Research, Third Military Medical University, Chongqing, 400042, People's 
      Republic of China.
FAU - Zhang, Xingcun
AU  - Zhang X
AD  - Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of 
      Surgery Research, Third Military Medical University, Chongqing, 400042, People's 
      Republic of China.
FAU - Yang, Yadong
AU  - Yang Y
AD  - Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of 
      Surgery Research, Third Military Medical University, Chongqing, 400042, People's 
      Republic of China.
FAU - Zhang, Junbo
AU  - Zhang J
AD  - Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of 
      Surgery Research, Third Military Medical University, Chongqing, 400042, People's 
      Republic of China.
FAU - Yang, Yunchuan
AU  - Yang Y
AD  - Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of 
      Surgery Research, Third Military Medical University, Chongqing, 400042, People's 
      Republic of China.
FAU - Lu, Yuangang
AU  - Lu Y
AD  - Department of Plastic and Cosmetic Surgery, Daping Hospital & Institute of 
      Surgery Research, Third Military Medical University, Chongqing, 400042, People's 
      Republic of China. 11794643@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20170214
PL  - India
TA  - Indian J Pediatr
JT  - Indian journal of pediatrics
JID - 0417442
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
CIN - Indian J Pediatr. 2017 Nov;84(11):889-890. PMID: 28653136
MH  - Administration, Cutaneous
MH  - Female
MH  - Hemangioma, Cavernous/*drug therapy/pathology
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Propranolol/administration & dosage/adverse effects/*therapeutic use
MH  - Skin Neoplasms/*drug therapy/pathology
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Efficacy
OT  - Infant
OT  - Safety
OT  - Strawberry hemangiomas
OT  - Topical propranolol
OT  - beta-adrenergic receptor blocker
EDAT- 2017/02/15 06:00
MHDA- 2018/03/24 06:00
CRDT- 2017/02/15 06:00
PHST- 2016/09/18 00:00 [received]
PHST- 2017/01/30 00:00 [accepted]
PHST- 2017/02/15 06:00 [pubmed]
PHST- 2018/03/24 06:00 [medline]
PHST- 2017/02/15 06:00 [entrez]
AID - 10.1007/s12098-017-2303-7 [pii]
AID - 10.1007/s12098-017-2303-7 [doi]
PST - ppublish
SO  - Indian J Pediatr. 2017 Jun;84(6):425-429. doi: 10.1007/s12098-017-2303-7. Epub 
      2017 Feb 14.