PMID- 28195823
OWN - NLM
STAT- MEDLINE
DCOM- 20170421
LR  - 20240213
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 283
IP  - 2
DP  - 2017 May
TI  - Clinical Safety of Bariatric Arterial Embolization: Preliminary Results of the 
      BEAT Obesity Trial.
PG  - 598-608
LID - 10.1148/radiol.2016160914 [doi]
AB  - Purpose To conduct a pilot prospective clinical trial to evaluate the 
      feasibility, safety, and short-term efficacy of bariatric embolization, a 
      recently developed endovascular procedure for the treatment of obesity, in 
      patients with severe obesity. Materials and Methods This is an institutional 
      review board- and U.S. Food and Drug Administration-approved prospective 
      physician-initiated investigational device exemption study. This phase of the 
      study ran from June 2, 2014, to August 4, 2015. Five severely obese patients 
      (four women, one man) who were 31-49 years of age and who had a mean body mass 
      index of 43.8 kg/m(2) +/- 2.9 with no clinically important comorbidities were 
      enrolled in this study. Transarterial embolization of the gastric fundus with 
      fluoroscopic guidance was performed with 300-500-mum Embosphere microspheres. The 
      primary end point was 30-day adverse events (AEs). The secondary end points 
      included short-term weight loss, serum obesity-related hormone levels, hunger and 
      satiety assessments, and quality of life (QOL) surveys, reported up to 3 months. 
      Simple statistics of central tendencies and variability were calculated. No 
      hypothesis testing was performed. Results The left gastric artery, with or 
      without the gastroepiploic artery, was embolized in five patients, with a 
      technical success rate of 100%. There were no major AEs. There were two minor 
      AEs-subclinical pancreatitis and a mucosal ulcer that had healed by the time of 
      3-month endoscopy. A hospital stay of less than 48 hours for routine supportive 
      care was provided for three patients. Mean excess weight loss of 5.9% +/- 2.4 and 
      9.0% +/- 4.1 was noted at 1 month and at 3 months, respectively. Mean change in 
      serum ghrelin was 8.7% +/- 34.7 and -17.5% +/- 29 at 1 month and 3 months, 
      respectively. Mean changes in serum glucagon-like peptide 1 and peptide YY were 
      106.6% +/- 208.5 and 17.8% +/- 54.8 at 1 month. There was a trend toward improvement 
      in QOL parameters. Hunger/appetite scores decreased in the first 2 weeks after 
      the procedure and then rose without reaching preprocedure levels. Conclusion 
      Bariatric embolization is feasible and appears to be well tolerated in severely 
      obese patients. In this small patient cohort, it appears to induce appetite 
      suppression and may induce weight loss. Further expansion of this study will 
      provide more insight into the long-term safety and efficacy of bariatric 
      embolization. ((c)) RSNA, 2017 Online supplemental material is available for this 
      article.
FAU - Weiss, Clifford R
AU  - Weiss CR
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Akinwande, Olaguoke
AU  - Akinwande O
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Paudel, Kaylan
AU  - Paudel K
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Cheskin, Lawrence J
AU  - Cheskin LJ
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Holly, Brian
AU  - Holly B
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Hong, Kelvin
AU  - Hong K
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Fischman, Aaron M
AU  - Fischman AM
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Patel, Rahul S
AU  - Patel RS
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Shin, Eun J
AU  - Shin EJ
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Steele, Kimberley E
AU  - Steele KE
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Moran, Timothy H
AU  - Moran TH
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Kaiser, Kristen
AU  - Kaiser K
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Park, Amie
AU  - Park A
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Shade, David M
AU  - Shade DM
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Kraitchman, Dara L
AU  - Kraitchman DL
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
FAU - Arepally, Aravind
AU  - Arepally A
AD  - From the Departments of Radiology (C.R.W., O.A., K.P., B.H., K.H., D.L.K.), 
      Gastroenterology and Hepatology (E.J.S.), Surgery (K.E.S.), and Psychiatry 
      (T.H.M.), Johns Hopkins University School of Medicine, Sheikh Zayed Tower, Suite 
      7203, 1800 Orleans St, Baltimore, MD 21287; Bloomberg School of Public Health, 
      Johns Hopkins University, Baltimore, Md (L.J.C.); Department of Interventional 
      Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.M.F., 
      R.S.P.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, Md (K.K., A.P., D.M.S.); and Department of Radiology, Piedmont 
      Healthcare, Atlanta, Ga (A.A.).
LA  - eng
GR  - R01 EB017615/EB/NIBIB NIH HHS/United States
GR  - T32 EB006351/EB/NIBIB NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20170214
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
RN  - 0 (Hemostatics)
SB  - IM
MH  - Adult
MH  - Embolization, Therapeutic/adverse effects/*methods
MH  - Female
MH  - Hemostatics/adverse effects/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/*diagnostic imaging/*therapy
MH  - Pilot Projects
MH  - Radiography, Interventional/*methods
MH  - Stomach/*blood supply
MH  - Treatment Outcome
PMC - PMC5410948
EDAT- 2017/02/15 06:00
MHDA- 2017/04/22 06:00
PMCR- 2018/05/01
CRDT- 2017/02/15 06:00
PHST- 2017/02/15 06:00 [pubmed]
PHST- 2017/04/22 06:00 [medline]
PHST- 2017/02/15 06:00 [entrez]
PHST- 2018/05/01 00:00 [pmc-release]
AID - 10.1148/radiol.2016160914 [pii]
AID - 10.1148/radiol.2016160914 [doi]
PST - ppublish
SO  - Radiology. 2017 May;283(2):598-608. doi: 10.1148/radiol.2016160914. Epub 2017 Feb 
      14.