PMID- 28196059
OWN - NLM
STAT- MEDLINE
DCOM- 20180524
LR  - 20180524
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 38
IP  - 2
DP  - 2018 Feb
TI  - QUANTIFICATION OF INTRARETINAL HARD EXUDATES IN EYES WITH DIABETIC RETINOPATHY BY 
      OPTICAL COHERENCE TOMOGRAPHY.
PG  - 231-236
LID - 10.1097/IAE.0000000000001545 [doi]
AB  - PURPOSE: To evaluate the reproducibility of intraretinal hard exudate (HE) 
      quantification from spectral domain optical coherence tomography (SD-OCT) images 
      of eyes with diabetic retinopathy (DR). METHODS: Cases with diabetic macular 
      edema were enrolled. The area of HE obtained by B-scan segmentation was compared 
      with the area obtained by en face segmentation. RESULTS: The mean +/- SD for the HE 
      area was 1.78 +/- 1.37 mm with B-scan segmentation and 0.72 +/- 0.82 mm with the 
      automated en face analysis tool; the absolute difference was 1.01 +/- 0.64 mm. 
      There was excellent correlation in total HE area between the two methods (r = 
      0.95, P < 0.0001). The HE volume was 0.06 +/- 0.07 mm. The correlation between HE 
      volume and en face HE area was high (r = 0.95, P < 0.001). Intergrader 
      reproducibility yielded excellent agreement with an intraclass correlation 
      coefficient value of 0.99 (95% CI 0.994-0.999) for the en face approach and 0.99 
      (95% CI 0.977-0.997) for manual segmentation. CONCLUSION: Quantification of HE in 
      eyes with diabetic retinopathy can be performed reliably using en face 
      segmentation and, though the en face results are consistently lower, correlates 
      well with HE measurements obtained by exhaustive segmentation of all B-scans in 
      dense volume optical coherence tomography (OCT).
FAU - Srinivas, Sowmya
AU  - Srinivas S
AD  - Doheny Eye Institute, Los Angeles, California.
FAU - Nittala, Muneeswar G
AU  - Nittala MG
AD  - Doheny Eye Institute, Los Angeles, California.
FAU - Hariri, Amirhossein
AU  - Hariri A
AD  - Doheny Eye Institute, Los Angeles, California.
FAU - Pfau, Maximilian
AU  - Pfau M
AD  - Doheny Eye Institute, Los Angeles, California.
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Gasperini, Julie
AU  - Gasperini J
AD  - Carson McBeath and Boswell Inc, South Coast Retina Center, Long Beach, 
      California.
FAU - Ip, Michael
AU  - Ip M
AD  - Doheny Eye Institute, Los Angeles, California.
AD  - Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los 
      Angeles, California.
FAU - Sadda, SriniVas R
AU  - Sadda SR
AD  - Doheny Eye Institute, Los Angeles, California.
AD  - Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los 
      Angeles, California.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
SB  - IM
MH  - Diabetic Retinopathy/*complications/diagnosis/physiopathology
MH  - Follow-Up Studies
MH  - Humans
MH  - Macula Lutea/*pathology
MH  - Macular Edema/*diagnosis/etiology/physiopathology
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Acuity
EDAT- 2017/02/15 06:00
MHDA- 2018/05/25 06:00
CRDT- 2017/02/15 06:00
PHST- 2017/02/15 06:00 [pubmed]
PHST- 2018/05/25 06:00 [medline]
PHST- 2017/02/15 06:00 [entrez]
AID - 10.1097/IAE.0000000000001545 [doi]
PST - ppublish
SO  - Retina. 2018 Feb;38(2):231-236. doi: 10.1097/IAE.0000000000001545.