PMID- 28197082
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 11
DP  - 2017
TI  - The Role of Acetaldehyde in the Increased Acceptance of Ethanol after Prenatal 
      Ethanol Exposure.
PG  - 14
LID - 10.3389/fnbeh.2017.00014 [doi]
LID - 14
AB  - Recent studies show that acetaldehyde, the first metabolite in the oxidation of 
      ethanol, can be responsible for both, the appetitive and the aversive effects 
      produced by ethanol intoxication. More specifically, it has been hypothesized 
      that acetaldehyde produced in the periphery by the liver is responsible for the 
      aversive effects of ethanol, while the appetitive effects relate to the 
      acetaldehyde produced centrally through the catalase system. On the other hand, 
      from studies in our and other laboratories, it is known that ethanol exposure 
      during the last gestational days (GD) consistently enhances the postnatal 
      acceptance of ethanol when measured during early ontogeny in the rat. This 
      increased liking of ethanol is a conditioned appetitive response acquired by the 
      fetus by the association of ethanol's flavor and an appetitive reinforcer. 
      Although this reinforcer has not yet been fully identified, one possibility 
      points to acetaldehyde produced centrally in the fetus as a likely candidate. 
      This hypothesis is supported by data showing that very early in the rat's 
      ontogeny brain catalases are functional, while the liver's enzymatic system is 
      still immature. In this study, rat dams were administered on GD 17-20 with water 
      or ethanol, together with an acetaldehyde-sequestering agent (D-penicillamine). 
      The offspring's responses to ethanol was then assessed at different postnatal 
      stages with procedures adequate for each developmental stage: on day 1, using the 
      "odor crawling locomotion test" to measure ethanol's odor attractiveness; on day 
      5, in an operant conditioning procedure with ethanol as the reinforcer; and on 
      day 14 in an ethanol intake test. Results show that the absence of acetaldehyde 
      during prenatal ethanol exposure impeded the observation of the increased 
      acceptance of ethanol at any age. This seems to confirm the crucial role of 
      acetaldehyde as a reinforcer in the appetitive learning occurring during prenatal 
      ethanol exposure.
FAU - Gaztanaga, Mirari
AU  - Gaztanaga M
AD  - Departamento de Procesos Psicologicos Basicos y su Desarrollo, Facultad de 
      Psicologia, University of the Basque Country UPV/EHU, Donostia-San Sebastian 
      Gipuzkoa, Spain.
FAU - Angulo-Alcalde, Asier
AU  - Angulo-Alcalde A
AD  - Departamento de Procesos Psicologicos Basicos y su Desarrollo, Facultad de 
      Psicologia, University of the Basque Country UPV/EHU, Donostia-San Sebastian 
      Gipuzkoa, Spain.
FAU - Spear, Norman E
AU  - Spear NE
AD  - Department of Psychology, Centre for Development and Behavioral Neuroscience, 
      Binghamton University Binghamton, NY, USA.
FAU - Chotro, M Gabriela
AU  - Chotro MG
AD  - Departamento de Procesos Psicologicos Basicos y su Desarrollo, Facultad de 
      Psicologia, University of the Basque Country UPV/EHU, Donostia-San Sebastian 
      Gipuzkoa, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170131
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC5281627
OTO - NOTNLM
OT  - acetaldehyde
OT  - ethanol intake
OT  - infant rat
OT  - odor attractiveness
OT  - operant conditioning
OT  - prenatal ethanol
EDAT- 2017/02/16 06:00
MHDA- 2017/02/16 06:01
PMCR- 2017/01/01
CRDT- 2017/02/16 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/01/16 00:00 [accepted]
PHST- 2017/02/16 06:00 [entrez]
PHST- 2017/02/16 06:00 [pubmed]
PHST- 2017/02/16 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2017.00014 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2017 Jan 31;11:14. doi: 10.3389/fnbeh.2017.00014. 
      eCollection 2017.