PMID- 28197269
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1923-2829 (Print)
IS  - 1923-2837 (Electronic)
IS  - 1923-2829 (Linking)
VI  - 7
IP  - 2
DP  - 2016 Apr
TI  - Measuring B-Type Natriuretic Peptide From Capillary Blood or Venous Sample: Is It 
      the Same?
PG  - 51-58
LID - 10.14740/cr468e [doi]
AB  - BACKGROUND: In recent years, several systems have been implemented to achieve 
      quick and non-invasive measurements of B-type natriuretic peptide (BNP). Among 
      them, Alere(TM) Heart Check (AHC) BNP test represents the most recent 
      advancement. It is a rapid point-of-care (POC) immunoassay, projected for 
      measuring BNP directly from a capillary whole blood sample. This study aimed at 
      comparing the analytical and clinical performances of this new POC to our 
      reference method (Abbott Architect System). METHODS: One hundred eleven patients 
      with stable chronic heart failure (CHF) referring to one cardiac rehabilitation 
      center were enrolled from December 2013 to May 2015. These patients were 
      subjected to a simultaneous capillary (AHC) and plasma (Abbott) BNP measurements. 
      Clinical and analytical performances of AHC were assessed and compared to the 
      reference method. RESULTS: Capillary BNP showed a good correlation with the 
      reference method (r = 0.94, P < 0.0001), although the values diverged when BNP 
      was higher than 1,500 pg/mL. Indeed, the AHC had a relatively poor precision and 
      the coefficient of variability was 10.1% and 18% for low and high controls, 
      respectively. However, both methods showed similar diagnostic performances in 
      discriminating the patients with heart failure in New York Heart Association 
      (NYHA) class I from those belonging to NYHA classes II-III, with values of area 
      under the curve (AUC) of 0.983 and 0.984, respectively, and equivalent 
      sensitivity, specificity, and positive and negative likelihood ratios. 
      CONCLUSION: The AHC BNP test is a good POC able to provide reliable information 
      about the hemodynamic status of CHF patients, especially of those belonging to 
      NYHA classes I-III.
FAU - De Vecchis, Renato
AU  - De Vecchis R
AD  - Cardiology Unit, Presidio Sanitario Intermedio "Elena d'Aosta", ASL Napoli 1 
      Centro, Napoli, Italy.
FAU - Ariano, Carmelina
AU  - Ariano C
AD  - Cardiology Unit, Presidio Sanitario Intermedio "Elena d'Aosta", ASL Napoli 1 
      Centro, Napoli, Italy.
LA  - eng
PT  - Journal Article
DEP - 20160504
PL  - Canada
TA  - Cardiol Res
JT  - Cardiology research
JID - 101557543
PMC - PMC5295542
OTO - NOTNLM
OT  - B-type natriuretic peptide
OT  - Capillary blood
OT  - Heart failure
OT  - Immunoassay
OT  - Point-of-care
OT  - Venous blood
EDAT- 2017/02/16 06:00
MHDA- 2017/02/16 06:01
PMCR- 2016/04/01
CRDT- 2017/02/16 06:00
PHST- 2016/04/15 00:00 [accepted]
PHST- 2017/02/16 06:00 [entrez]
PHST- 2017/02/16 06:00 [pubmed]
PHST- 2017/02/16 06:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 10.14740/cr468e [doi]
PST - ppublish
SO  - Cardiol Res. 2016 Apr;7(2):51-58. doi: 10.14740/cr468e. Epub 2016 May 4.