PMID- 28198994
OWN - NLM
STAT- MEDLINE
DCOM- 20181003
LR  - 20181004
IS  - 2543-6031 (Electronic)
IS  - 2451-4934 (Linking)
VI  - 85
IP  - 1
DP  - 2017
TI  - Interstitial pneumonia with autoimmune features (IPAF) and radiological findings 
      suggestive of lymphocytic interstitial pneumonia (LIP) - case report.
PG  - 46-50
LID - 10.5603/ARM.2017.0009 [doi]
AB  - Interstitial pneumonia with autoimmune features (IPAF) is a term to describe 
      individuals with both interstitial lung disease (ILD) and combinations of other 
      clinical, serologic, and/or pulmonary morphologic features, which presumably 
      originate from an underlying systemic autoimmune condition, but do not meet 
      current rheumatologic criteria for a defined connective tissue disease (CTD). 
      Predominantly, interstitial pneumonia arises in the course of an established CTD, 
      but it is not so rare for the ILD to be the first, and possibly the one and only 
      manifestation of a latent CTD. Lymphocytic Interstitial Pneumonia (LIP) is an 
      uncommon disease, characterized by infiltration of the interstitium and alveolar 
      spaces of the lung by lymphocytes, plasma cells and other lymphoreticular 
      elements. The cause of LIP is still unknown but it could be also a manifestation 
      of CTD. Clinically, it is highly variable, from spontaneous resolution to 
      progressive respiratory failure and death despite glucocorticoid treatment. Since 
      there are no recent standards for the management of LIP, the disease is treated 
      empirically. We report a case of a HIV-negative 54-year-old woman, who was 
      suspected of LIP according to clinical features and radiological findings. 
      Positive laboratory results were highly suggestive of underlying autoimmune 
      process, but did not fulfil the criteria of any particular CTD. Because of severe 
      general condition of the patient, immunosuppressive treatment was started 
      immediately, without further invasive diagnostics including lung biopsy, which is 
      required for a definitive diagnosis. We present two-year observation of the 
      patient with all our doubts concerning clinical proceedings.
FAU - Plociniczak, Alicja
AU  - Plociniczak A
AD  - petit_rayon@tlen.pl.
FAU - Gozdzik-Spychalska, Joanna
AU  - Gozdzik-Spychalska J
FAU - Batura-Gabryel, Halina Batura-Gabryel
AU  - Batura-Gabryel HB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Switzerland
TA  - Adv Respir Med
JT  - Advances in respiratory medicine
JID - 101697329
RN  - 0 (Immunosuppressive Agents)
RN  - Lymphoid Interstitial Pneumonia
SB  - IM
MH  - Connective Tissue Diseases/*complications/*diagnostic imaging/drug therapy
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/*complications/*diagnostic imaging/*drug 
      therapy
MH  - Immunosuppressive Agents/therapeutic use
MH  - Lung/diagnostic imaging
MH  - Lung Diseases, Interstitial/*complications/*diagnostic imaging/diet therapy
MH  - Middle Aged
OTO - NOTNLM
OT  - clinical suspicion
OT  - immunosuppressive treatment
OT  - interstitial pneumonia with autoimmune features
OT  - lymphocytic interstitial pneumonia
EDAT- 2017/02/16 06:00
MHDA- 2018/10/04 06:00
CRDT- 2017/02/16 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/02/16 06:00 [entrez]
PHST- 2017/02/16 06:00 [pubmed]
PHST- 2018/10/04 06:00 [medline]
AID - VM/OJS/J/50682 [pii]
AID - 10.5603/ARM.2017.0009 [doi]
PST - ppublish
SO  - Adv Respir Med. 2017;85(1):46-50. doi: 10.5603/ARM.2017.0009.