PMID- 28199041
OWN - NLM
STAT- MEDLINE
DCOM- 20180712
LR  - 20181127
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 46
IP  - 5
DP  - 2017 Nov
TI  - Feasibility of accelerated simultaneous multislice diffusion-weighted MRI of the 
      prostate.
PG  - 1507-1515
LID - 10.1002/jmri.25665 [doi]
AB  - PURPOSE: To assess the feasibility of simultaneous multislice (SMS) single-shot 
      echo-planar-imaging (EPI) for accelerated diffusion-weighted imaging (DWI) of the 
      prostate. MATERIALS AND METHODS: For phantom measurements a dedicated DWI phantom 
      with different sucrose concentrations was used. In addition, 10 volunteers and 16 
      patients with suspected prostate cancer were examined for in vivo measurements. 
      All examinations were performed with a 3T magnetic resonance imaging (MRI) 
      system. A prototype simultaneous multislice EPI sequence (DW-EPI(SMS) ; 
      acquisition time 3:14 min) was acquired and compared to a single-shot EPI 
      sequence (DW-EPI(SS) ; acquisition time 6:12 min) serving as a standard of 
      reference. Different image quality parameters of EPI(SMS) were assessed 
      qualitatively (overall image quality, anatomic differentiability, lesion 
      conspicuity, image noise, distortion; two independent readers; 5-point 
      Likert-scale [5 = excellent]) and quantitatively (ADC-values by calculating 
      interclass correlation [ICC] and Bland-Altman limits of agreement [LoA] as 
      measures for reproducibility) and compared to DW-EPI(SS) . RESULTS: DW-EPI(SMS) 
      allowed for a substantially reduced acquisition time as compared to DW-EPI(SS) 
      ( 50%). Bland-Altman plots revealed robust measurement repeatability for 
      DW-EPI(SMS) in the phantom study. Overall image quality did not significantly 
      differ between DW-EPI(SMS) and DW-EPI(SS) (b1500 images P = 0.5; ADC maps 
      P = 0.7). Only in b1500 DW images was subjective image noise rated significantly 
      higher in DW-EPI(SS) than in DW-EPI(SMS) (P = 0.006). Quantitative analysis of 
      ADC-values revealed not significant differences between DW-EPI(SMS) and 
      DW-EPI(SS) (P = 0.7) and high measures for reproducibility ICC >/=0.96. CONCLUSION: 
      Simultaneous multislice DWI is feasible for accelerated prostate MRI allowing for 
      a substantially reduced examination time with similar image quality and 
      ADC-values as compared to a standard of reference DWI sequence. LEVEL OF 
      EVIDENCE: 3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 
      2017;46:1507-1515.
CI  - (c) 2017 International Society for Magnetic Resonance in Medicine.
FAU - Weiss, Jakob
AU  - Weiss J
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University 
      Tuebingen, Germany.
FAU - Martirosian, Petros
AU  - Martirosian P
AD  - Section on Experimental Radiology, Eberhard Karls University Tuebingen, Germany.
FAU - Taron, Jana
AU  - Taron J
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University 
      Tuebingen, Germany.
FAU - Othman, Ahmed E
AU  - Othman AE
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University 
      Tuebingen, Germany.
FAU - Kuestner, Thomas
AU  - Kuestner T
AD  - Institute of Signal Processing and System Theory, University of Stuttgart, 
      Germany.
FAU - Erb, Michael
AU  - Erb M
AD  - Department of Biomedical Magnetic Resonance, Eberhard Karls University Tuebingen, 
      Germany.
FAU - Bedke, Jens
AU  - Bedke J
AD  - Department of Urology, Eberhard Karls University Tuebingen, Germany.
FAU - Bamberg, Fabian
AU  - Bamberg F
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University 
      Tuebingen, Germany.
FAU - Nikolaou, Konstantin
AU  - Nikolaou K
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University 
      Tuebingen, Germany.
FAU - Notohamiprodjo, Mike
AU  - Notohamiprodjo M
AD  - Department of Diagnostic and Interventional Radiology, Eberhard Karls University 
      Tuebingen, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170215
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
SB  - IM
MH  - Adult
MH  - Aged
MH  - Artifacts
MH  - Case-Control Studies
MH  - *Diffusion Magnetic Resonance Imaging
MH  - *Echo-Planar Imaging
MH  - Feasibility Studies
MH  - Healthy Volunteers
MH  - Humans
MH  - Image Enhancement
MH  - Image Interpretation, Computer-Assisted
MH  - Male
MH  - Middle Aged
MH  - Phantoms, Imaging
MH  - Prostate/*diagnostic imaging
MH  - Prostatic Neoplasms/*diagnostic imaging
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - accelerated prostate MRI
OT  - diffusion-weighted imaging
OT  - prostate cancer
OT  - simultaneous multislice acquisition
EDAT- 2017/02/16 06:00
MHDA- 2018/07/13 06:00
CRDT- 2017/02/16 06:00
PHST- 2016/09/01 00:00 [received]
PHST- 2017/01/25 00:00 [accepted]
PHST- 2017/02/16 06:00 [pubmed]
PHST- 2018/07/13 06:00 [medline]
PHST- 2017/02/16 06:00 [entrez]
AID - 10.1002/jmri.25665 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2017 Nov;46(5):1507-1515. doi: 10.1002/jmri.25665. Epub 
      2017 Feb 15.