PMID- 28199140
OWN - NLM
STAT- MEDLINE
DCOM- 20170814
LR  - 20170814
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Linking)
VI  - 96
IP  - 5
DP  - 2017 May
TI  - Role of Bone Marrow Stromal Cells in Impaired Bone Repair from BRONJ Osseous 
      Lesions.
PG  - 539-546
LID - 10.1177/0022034517691507 [doi]
AB  - Treatment of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has posed 
      significant challenges to maxillofacial surgeons because of the poor repair of 
      BRONJ bone defects. Moreover, the pathological mechanisms remain unclear. Bone 
      marrow stromal cells (BMSCs) play key roles during bone repair and bone 
      regeneration. However, the activities of BMSCs derived from BRONJ lesions and the 
      BRONJ lesion boundary, as well as the roles of BMSCs in BRONJ defect repair, are 
      poorly defined. In this study, we found that BMSCs from the central area of the 
      osteonecrotic BRONJ region (center-BRONJ BMSCs) and the peripheral area at the 
      recommended debridement boundary (peri-BRONJ BMSCs) had decreased proliferative 
      ability, self-renewal capacity, and multidifferentiation capacities compared with 
      control BMSCs. Osteoclast-inducing ability was also impaired in BRONJ BMSCs. All 
      of these results suggested that the decreased activities of BRONJ BMSCs, even the 
      BMSCs derived from the BRONJ lesion boundary, might be an important factor 
      leading to insufficient bone repair of BRONJ lesions. This study offers early 
      stage evidence for the use of marrow stromal cells in the treatment of BRONJ.
FAU - He, L H
AU  - He LH
AD  - 1 Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
FAU - Xiao, E
AU  - Xiao E
AD  - 1 Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
FAU - An, J G
AU  - An JG
AD  - 1 Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
FAU - He, Y
AU  - He Y
AD  - 1 Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
FAU - Chen, S
AU  - Chen S
AD  - 1 Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
FAU - Zhao, L
AU  - Zhao L
AD  - 1 Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
FAU - Zhang, T
AU  - Zhang T
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
AD  - 3 Center for Craniofacial Stem Cell Research and Regeneration, Department of 
      Orthodontics, Peking University School and Hospital of Stomatology, Beijing, 
      China.
FAU - Zhang, Y
AU  - Zhang Y
AD  - 1 Department of Oral and Maxillofacial Surgery, Peking University School and 
      Hospital of Stomatology, Beijing, China.
AD  - 2 National Engineering Laboratory for Digital and Material Technology of 
      Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20170215
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Bisphosphonate-Associated Osteonecrosis of the Jaw/*therapy
MH  - Blotting, Western
MH  - Bone Marrow Cells/*cytology
MH  - Bone Marrow Transplantation
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Coculture Techniques
MH  - Debridement
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Male
MH  - Mice
MH  - Mice, Nude
MH  - Middle Aged
MH  - RNA/analysis
MH  - Real-Time Polymerase Chain Reaction
MH  - Stromal Cells/*cytology/transplantation
OTO - NOTNLM
OT  - bone resorption
OT  - cell differentiation
OT  - osteoblast
OT  - osteoclast
OT  - osteogenesis
OT  - osteonecrosis
EDAT- 2017/02/16 06:00
MHDA- 2017/08/15 06:00
CRDT- 2017/02/16 06:00
PHST- 2017/02/16 06:00 [pubmed]
PHST- 2017/08/15 06:00 [medline]
PHST- 2017/02/16 06:00 [entrez]
AID - 10.1177/0022034517691507 [doi]
PST - ppublish
SO  - J Dent Res. 2017 May;96(5):539-546. doi: 10.1177/0022034517691507. Epub 2017 Feb 
      15.