PMID- 28202225
OWN - NLM
STAT- MEDLINE
DCOM- 20180201
LR  - 20221207
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 101
DP  - 2017 Apr
TI  - Persistent organic pollutants and diabetes among Inuit in the Canadian Arctic.
PG  - 183-189
LID - S0160-4120(16)30981-3 [pii]
LID - 10.1016/j.envint.2017.02.002 [doi]
AB  - Type 2 diabetes is a chronic metabolic disease that is of increasing concern in 
      Inuit communities. Behavioural factors such as physical inactivity and poor diet 
      are well-known risk factors. Exposure to persistent organic pollutants (POPs) has 
      emerged as an additional factor in the pathogenesis of diabetes. In this study, 
      association between polychlorinated biphenyls (PCBs) and 
      p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) with diabetes in Canadian Inuit 
      was examined. Data from the Adult Inuit Health Survey (2007-2008) of Inuit 
      participants from the Canadian Arctic were analyzed. Self-reported diabetes 
      (excluding gestational diabetes) and clinical measurement of fasting glucose were 
      examined as outcomes. Association with individual PCB congeners, sum of 
      dioxin-like PCBs ( summation operatorDL-PCB), non-dioxin-like PCBs ( summation operatorNDL-PCB), total PCBs ( summation operatorPCB), 
      and p,p'-DDE were investigated using multiple regression models adjusted for 
      confounding factors. Using different methods to incorporate serum lipids, highest 
      vs. lowest quartile exposures to PCB-105, PCB-118, PCB-153, PCB-156, PCB-170, 
      PCB-180, PCB-183,  summation operatorPCB, and p,p'-DDE were associated with increased risk of 
      diabetes. For these PCBs, odds ratios (ORs) ranged from 1.9-3.5 (lower 95% CI: 
      0.8-1.4, upper 95% CI: 4.4-9.0) and for p,p'-DDE the OR was 2.5 (lower 95% CI: 
      1.1-1.2, upper 95% CI: 5.9-6.0). The highest vs. lowest quartile exposure to most 
      PCBs and p,p'-DDE were associated with an increase of fasting glucose by 3-7%. 
      PCBs and p,p'-DDE were associated with increased risk of diabetes and higher 
      fasting glucose level in a cross-sectional survey of Canadian Inuit. Cause-effect 
      relationships of PCBs and p,p'-DDE with diabetes and diabetes-related outcomes 
      need to be further investigated in a cohort study.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Singh, Kavita
AU  - Singh K
AD  - Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada. Electronic 
      address: ksing075@uottawa.ca.
FAU - Chan, Hing Man
AU  - Chan HM
AD  - Department of Biology, University of Ottawa, Ontario K1N 6N5, Canada. Electronic 
      address: laurie.chan@uottawa.ca.
LA  - eng
PT  - Journal Article
DEP - 20170213
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arctic Regions
MH  - Canada/epidemiology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/ethnology/etiology/prevention & control
MH  - Dichlorodiphenyl Dichloroethylene/*analysis/blood
MH  - Environmental Exposure/adverse effects
MH  - Environmental Pollutants/*analysis/blood
MH  - Female
MH  - Humans
MH  - Inuit
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/*analysis/blood
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - *Canada
OT  - *Diabetes
OT  - *Inuit
OT  - *Persistent organic pollutants
EDAT- 2017/02/17 06:00
MHDA- 2018/02/02 06:00
CRDT- 2017/02/17 06:00
PHST- 2016/12/06 00:00 [received]
PHST- 2017/02/02 00:00 [revised]
PHST- 2017/02/03 00:00 [accepted]
PHST- 2017/02/17 06:00 [pubmed]
PHST- 2018/02/02 06:00 [medline]
PHST- 2017/02/17 06:00 [entrez]
AID - S0160-4120(16)30981-3 [pii]
AID - 10.1016/j.envint.2017.02.002 [doi]
PST - ppublish
SO  - Environ Int. 2017 Apr;101:183-189. doi: 10.1016/j.envint.2017.02.002. Epub 2017 
      Feb 13.