PMID- 28202438
OWN - NLM
STAT- MEDLINE
DCOM- 20170627
LR  - 20200930
IS  - 1522-1490 (Electronic)
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 312
IP  - 4
DP  - 2017 Apr 1
TI  - Effect of food deprivation or short-term Western diet feeding on BDNF protein 
      expression in the hypothalamic arcuate, paraventricular, and ventromedial nuclei.
PG  - R611-R625
LID - 10.1152/ajpregu.00256.2016 [doi]
AB  - Mutations in the brain-derived neurotrophic factor (BDNF) gene are associated 
      with human obesity, and BDNF has potent inhibitory effects on eating and body 
      weight. Little is known about the effects of energy balance manipulations on BDNF 
      protein in the hypothalamus, though this brain region is critical for regulation 
      of feeding and body weight and has high levels of BDNF. Here we investigated the 
      effects of negative and positive energy status on BDNF protein levels in the 
      arcuate (ARC), paraventricular, and ventromedial (VMH) hypothalamic nuclei and 
      the ectorhinal cortex. To achieve this, mice were food deprived for 48 h or fed a 
      Western diet (WD), a restricted amount of WD, or chow for 6 h, 48 h, 1 wk, or 3 
      wk. BDNF protein levels were estimated as the number of neurons in each brain 
      region that exhibited BDNF-like immunoreactivity. Food deprivation decreased BDNF 
      protein (and mRNA) expression in the ARC compared with fed mice (32%). In 
      contrast, 1 wk of WD consumption increased BDNF protein expression in the VMH 
      compared with chow or restricted WD feeding (40%) and, unexpectedly, increased 
      BDNF protein in the ectorhinal cortex (20%). Furthermore, of the diet conditions 
      and durations tested, only 1 wk of WD consumption was associated with both 
      hyperphagia and excess weight, suggesting that effects of one or both contributed 
      to the changes in BDNF levels. The decrease in ARC BDNF may support increased 
      feeding in food-deprived mice, whereas the increase in the VMH may moderate 
      overeating in WD-fed mice.
CI  - Copyright (c) 2017 the American Physiological Society.
FAU - Gilland, Kaitlyn E
AU  - Gilland KE
AD  - Behavioral Neurogenetics Laboratory, Department of Psychological Sciences, Purdue 
      University, West Lafayette, Indiana.
FAU - Fox, Edward A
AU  - Fox EA
AD  - Behavioral Neurogenetics Laboratory, Department of Psychological Sciences, Purdue 
      University, West Lafayette, Indiana au_gc@psych.purdue.edu.
LA  - eng
GR  - T32 DK076540/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20170215
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Arcuate Nucleus of Hypothalamus/*metabolism
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - *Diet, Western
MH  - Eating/physiology
MH  - Food Deprivation/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Paraventricular Hypothalamic Nucleus/*metabolism
MH  - Tissue Distribution
MH  - Ventromedial Hypothalamic Nucleus/*metabolism
PMC - PMC7132316
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - food intake
OT  - obesity
COIS- No conflicts of interest, financial or otherwise, are declared by the authors.
EDAT- 2017/02/17 06:00
MHDA- 2017/06/28 06:00
PMCR- 2018/04/01
CRDT- 2017/02/17 06:00
PHST- 2016/06/14 00:00 [received]
PHST- 2017/02/01 00:00 [revised]
PHST- 2017/02/06 00:00 [accepted]
PHST- 2017/02/17 06:00 [pubmed]
PHST- 2017/06/28 06:00 [medline]
PHST- 2017/02/17 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - ajpregu.00256.2016 [pii]
AID - R-00256-2016 [pii]
AID - 10.1152/ajpregu.00256.2016 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2017 Apr 1;312(4):R611-R625. doi: 
      10.1152/ajpregu.00256.2016. Epub 2017 Feb 15.