PMID- 28203206
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 8
DP  - 2017
TI  - Mild and Short-Term Caloric Restriction Prevents Obesity-Induced Cardiomyopathy 
      in Young Zucker Rats without Changing in Metabolites and Fatty Acids Cardiac 
      Profile.
PG  - 42
LID - 10.3389/fphys.2017.00042 [doi]
LID - 42
AB  - Caloric restriction (CR) ameliorates cardiac dysfunction associated with obesity. 
      However, most of the studies have been performed under severe CR (30-65% caloric 
      intake decrease) for several months or even years in aged animals. Here, we 
      investigated whether mild (20% food intake reduction) and short-term (2-weeks) CR 
      prevented the obese cardiomyopathy phenotype and improved the metabolic profile 
      of young (14 weeks of age) genetically obese Zucker fa/fa rats. Heart weight (HW) 
      and HW/tibia length ratio was significantly lower in fa/fa rats after 2 weeks of 
      CR than in counterparts fed ad libitum. Invasive pressure measurements showed 
      that systolic blood pressure, maximal rate of positive left ventricle (LV) 
      pressure, LV systolic pressure and LV end-diastolic pressure were all 
      significantly higher in obese fa/fa rats than in lean counterparts, which were 
      prevented by CR. Magnetic resonance imaging revealed that the increase in LV 
      end-systolic volume, stroke volume and LV wall thickness observed in fa/fa rats 
      was significantly lower in animals on CR diet. Histological analysis also 
      revealed that CR blocked the significant increase in cardiomyocyte diameter in 
      obese fa/fa rats. High resolution magic angle spinning magnetic resonance 
      spectroscopy analysis of the LV revealed a global decrease in metabolites such as 
      taurine, creatine and phosphocreatine, glutamate, glutamine and glutathione, in 
      obese fa/fa rats, whereas lactate concentration was increased. By contrast, fatty 
      acid concentrations in LV tissue were significantly elevated in obese fa/fa rats. 
      CR failed to restore the LV metabolomic profile of obese fa/fa rats. In 
      conclusion, mild and short-term CR prevented an obesity-induced cardiomyopathy 
      phenotype in young obese fa/fa rats independently of the cardiac metabolic 
      profile.
FAU - Ruiz-Hurtado, Gema
AU  - Ruiz-Hurtado G
AD  - Unidad de Hipertension, Instituto de Investigacion Imas12, Hospital Universitario 
      12 de OctubreMadrid, Spain; Facultad de Farmacia, Instituto Pluridisciplinar, 
      Universidad Complutense de MadridMadrid, Spain.
FAU - Garcia-Prieto, Concha F
AU  - Garcia-Prieto CF
AD  - Departamento de Ciencias Farmaceuticas y de la Salud, Facultad de Farmacia, 
      Universidad CEU-San Pablo Madrid, Spain.
FAU - Pulido-Olmo, Helena
AU  - Pulido-Olmo H
AD  - Unidad de Hipertension, Instituto de Investigacion Imas12, Hospital Universitario 
      12 de OctubreMadrid, Spain; Facultad de Farmacia, Instituto Pluridisciplinar, 
      Universidad Complutense de MadridMadrid, Spain.
FAU - Velasco-Martin, Juan P
AU  - Velasco-Martin JP
AD  - Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina. 
      Universidad Autonoma de Madrid Madrid, Spain.
FAU - Villa-Valverde, Palmira
AU  - Villa-Valverde P
AD  - CAI de RMN y RSE, Facultad de Quimicas, Universidad Complutense Madrid, Spain.
FAU - Fernandez-Valle, Maria E
AU  - Fernandez-Valle ME
AD  - CAI de RMN y RSE, Facultad de Quimicas, Universidad Complutense Madrid, Spain.
FAU - Bosca, Lisardo
AU  - Bosca L
AD  - Departamento de Metabolismo y Senalizacion Celular, Instituto de Investigaciones 
      Biomedicas Alberto Sols (CSIC-UAM) Madrid, Spain.
FAU - Fernandez-Velasco, Maria
AU  - Fernandez-Velasco M
AD  - Departamento de Metabolismo y Senalizacion Celular, Instituto de Investigaciones 
      Biomedicas Alberto Sols (CSIC-UAM)Madrid, Spain; Departamento de Metabolismo y 
      Senalizacion Celular, Instituto de Investigacion Hospital Universitario La Paz 
      (IdiPAZ)Madrid, Spain.
FAU - Regadera, Javier
AU  - Regadera J
AD  - Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina. 
      Universidad Autonoma de Madrid Madrid, Spain.
FAU - Somoza, Beatriz
AU  - Somoza B
AD  - Departamento de Ciencias Farmaceuticas y de la Salud, Facultad de Farmacia, 
      Universidad CEU-San Pablo Madrid, Spain.
FAU - Fernandez-Alfonso, Maria S
AU  - Fernandez-Alfonso MS
AD  - Facultad de Farmacia, Instituto Pluridisciplinar, Universidad Complutense de 
      Madrid Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170201
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC5285365
OTO - NOTNLM
OT  - caloric restriction
OT  - hypertension
OT  - hypertrophy
OT  - metabolite profile
OT  - nuclear magnetic resonance
OT  - obesity-induced cardiomyopathy
EDAT- 2017/02/17 06:00
MHDA- 2017/02/17 06:01
PMCR- 2017/02/01
CRDT- 2017/02/17 06:00
PHST- 2016/11/10 00:00 [received]
PHST- 2017/01/16 00:00 [accepted]
PHST- 2017/02/17 06:00 [entrez]
PHST- 2017/02/17 06:00 [pubmed]
PHST- 2017/02/17 06:01 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - 10.3389/fphys.2017.00042 [doi]
PST - epublish
SO  - Front Physiol. 2017 Feb 1;8:42. doi: 10.3389/fphys.2017.00042. eCollection 2017.