PMID- 28208185
OWN - NLM
STAT- MEDLINE
DCOM- 20170615
LR  - 20220408
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 58
IP  - 2
DP  - 2017 Feb 1
TI  - Evaluation of Progressive Visual Dysfunction and Retinal Degeneration in Patients 
      With Parkinson's Disease.
PG  - 1151-1157
LID - 10.1167/iovs.16-20460 [doi]
AB  - PURPOSE: To quantify changes in visual function parameters and in the retinal 
      nerve fiber layer and macular thickness over a 5-year period in patients with 
      Parkinson's disease (PD). METHODS: Thirty patients with PD and 30 healthy 
      subjects underwent a complete ophthalmic evaluation, including assessment of 
      visual acuity, contrast sensitivity vision, color vision, and retinal evaluation 
      with spectral-domain optical coherence tomography (SD-OCT). All subjects were 
      reevaluated after 5 years to quantify changes in visual function parameters, the 
      retinal nerve fiber layer, and macular thickness. Association between progressive 
      ophthalmologic changes and disease progression was analyzed. RESULTS: Changes 
      were detected in visual function parameters and retinal nerve fiber layer 
      thickness in patients compared with controls. Greater changes were found during 
      the follow-up in the PD group than healthy subjects in visual acuity, contrast 
      sensitivity, Lanthony color test (P < 0.016), in superotemporal and temporal 
      retinal nerve fiber layer sectors (P < 0.001), and in macular thickness (all 
      sectors except inner superior and inner inferior sectors, P < 0.001). Progressive 
      changes in the retinal nerve fiber layer were associated with disease progression 
      (r = 0.389, P = 0.028). CONCLUSIONS: Progressive visual dysfunction, macular 
      thinning, and axonal loss can be detected in PD. Analysis of the macular 
      thickness and the retinal nerve fiber layer by SD-OCT can be useful for 
      evaluating Parkinson's disease progression.
FAU - Satue, Maria
AU  - Satue M
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Rodrigo, Maria J
AU  - Rodrigo MJ
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Obis, Javier
AU  - Obis J
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Vilades, Elisa
AU  - Vilades E
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Gracia, Hector
AU  - Gracia H
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Otin, Sofia
AU  - Otin S
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Fuertes, Maria I
AU  - Fuertes MI
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Alarcia, Raquel
AU  - Alarcia R
AD  - Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain 3Neurology 
      Department, Miguel Servet University Hospital, Zaragoza, Spain.
FAU - Crespo, Jose A
AU  - Crespo JA
AD  - Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain 3Neurology 
      Department, Miguel Servet University Hospital, Zaragoza, Spain.
FAU - Polo, Vicente
AU  - Polo V
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Larrosa, Jose M
AU  - Larrosa JM
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Pablo, Luis E
AU  - Pablo LE
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
FAU - Garcia-Martin, Elena
AU  - Garcia-Martin E
AD  - Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain 
      2Aragon Health Research Institute (IIS Aragon, IACS), Zaragoza, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Color Vision/physiology
MH  - Contrast Sensitivity/physiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Macula Lutea/pathology
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/pathology
MH  - Parkinson Disease/*complications/physiopathology
MH  - Retina/*physiopathology
MH  - Retinal Degeneration/*physiopathology
MH  - Retinal Ganglion Cells/pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
EDAT- 2017/02/17 06:00
MHDA- 2017/06/16 06:00
CRDT- 2017/02/17 06:00
PHST- 2017/02/17 06:00 [entrez]
PHST- 2017/02/17 06:00 [pubmed]
PHST- 2017/06/16 06:00 [medline]
AID - 2604719 [pii]
AID - 10.1167/iovs.16-20460 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):1151-1157. doi: 
      10.1167/iovs.16-20460.