PMID- 28208226
OWN - NLM
STAT- MEDLINE
DCOM- 20170616
LR  - 20170616
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 67
IP  - 4
DP  - 2017 Apr
TI  - A rare case of TFE-related pigmented renal tumor with overlapping features 
      between melanotic Xp11 translocation renal cancer and Xp11 renal cell carcinoma 
      with melanotic features.
PG  - 208-213
LID - 10.1111/pin.12517 [doi]
AB  - In recent years, an increasing number of TFE3 rearrangement-associated tumors 
      with melanotic features have been reported as primary neoplasm in different 
      anatomical sites, including the kidney. Melanotic Xp11 translocation renal cancer 
      (MXTRC) and Xp11 renal cell carcinoma with melanotic features (XRCCM) have been 
      proposed to be main categories for pigmented lesions in the 
      microophthalmia-associated transcription factor (MiTF/TFE3) family of renal 
      tumors that may show variable degrees of melanocytic differentiation. Herein we 
      report a rare case of TFE3-related pigmented renal tumor showing unusual 
      immunoexpression of cytokeratins (AE1/AE3) and renal cell carcinoma markers (RCC, 
      CD10). Cathepsin-K and Vimentin were diffusely positive whereas melanocytic 
      markers (HMB-45 and Melan-A) displayed weak and patchy expression. We found no 
      labelling for PAX-8, muscle markers (desmin, smooth muscle actin, muscle-specific 
      actin and caldesmon) and S-100. TFE3 fusion was confirmed by break-apart 
      fluorescence in situ hybridization (FISH). This case corroborates previous 
      evidence for overlap in the TFE3-associated cancer family and illustrates that it 
      may not be possible to set a clear cutoff between epithelial (XRCCM) and 
      mesenchymal (MXTRC) subgroups.
CI  - (c) 2017 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
FAU - Cardili, Leonardo
AU  - Cardili L
AD  - Department of Pathology, Escola Paulista de Medicina/Universidade Federal de Sao 
      Paulo (EPM/UNIFESP), Sao Paulo, Brazil.
FAU - Wrublevsky Pereira, Gregorio
AU  - Wrublevsky Pereira G
AD  - Instituto de Oncologia Pediatrica (IOP/GRAAC), Sao Paulo, Brazil.
FAU - Viana, Cristiano Ribeiro
AU  - Viana CR
AD  - Department of Pathology, Hospital do Cancer de Barretos/Fundacao Pio XII, 
      Barretos, Brazil.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170216
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Basic Helix-Loop-Helix Leucine Zipper Transcription Factors)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (TFE3 protein, human)
SB  - IM
EIN - Pathol Int. 2017 Jun;67(6):330. PMID: 28573711
MH  - Adult
MH  - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/*genetics
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoma, Renal Cell/diagnosis/genetics/*pathology
MH  - *Chromosomes, Human, X
MH  - Female
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - Kidney Neoplasms/diagnosis/genetics/*pathology
MH  - Melanocytes/*pathology
MH  - Melanoma/diagnosis/genetics/*pathology
MH  - Translocation, Genetic/*genetics
OTO - NOTNLM
OT  - TFE3
OT  - Xp11
OT  - kidney
OT  - melanin
OT  - neoplasms
EDAT- 2017/02/17 06:00
MHDA- 2017/06/18 06:00
CRDT- 2017/02/17 06:00
PHST- 2016/12/16 00:00 [received]
PHST- 2017/01/27 00:00 [accepted]
PHST- 2017/02/17 06:00 [pubmed]
PHST- 2017/06/18 06:00 [medline]
PHST- 2017/02/17 06:00 [entrez]
AID - 10.1111/pin.12517 [doi]
PST - ppublish
SO  - Pathol Int. 2017 Apr;67(4):208-213. doi: 10.1111/pin.12517. Epub 2017 Feb 16.