PMID- 28208665
OWN - NLM
STAT- MEDLINE
DCOM- 20170428
LR  - 20240324
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 18
IP  - 2
DP  - 2017 Feb 11
TI  - Effect of Photon Hormesis on Dose Responses to Alpha Particles in Zebrafish 
      Embryos.
LID - 10.3390/ijms18020385 [doi]
LID - 385
AB  - Photon hormesis refers to the phenomenon where the biological effect of ionizing 
      radiation with a high linear energy transfer (LET) value is diminished by photons 
      with a low LET value. The present paper studied the effect of photon hormesis 
      from X-rays on dose responses to alpha particles using embryos of the zebrafish 
      (Danio rerio) as the in vivo vertebrate model. The toxicity of these ionizing 
      radiations in the zebrafish embryos was assessed using the apoptotic counts at 
      20, 24, or 30 h post fertilization (hpf) revealed through acridine orange (AO) 
      staining. For alpha-particle doses >/= 4.4 mGy, the additional X-ray dose of 10 mGy 
      significantly reduced the number of apoptotic cells at 24 hpf, which proved the 
      presence of photon hormesis. Smaller alpha-particle doses might not have 
      inflicted sufficient aggregate damages to trigger photon hormesis. The time gap T 
      between the X-ray (10 mGy) and alpha-particle (4.4 mGy) exposures was also 
      studied. Photon hormesis was present when T </= 30 min, but was absent when T = 60 
      min, at which time repair of damage induced by alpha particles would have 
      completed to prevent their interactions with those induced by X-rays. Finally, 
      the drop in the apoptotic counts at 24 hpf due to photon hormesis was explained 
      by bringing the apoptotic events earlier to 20 hpf, which strongly supported the 
      removal of aberrant cells through apoptosis as an underlying mechanism for photon 
      hormesis.
FAU - Ng, Candy Yuen Ping
AU  - Ng CY
AD  - Department of Physics and Materials Science, City University of Hong Kong, Hong 
      Kong, China. yuenpng3-c@my.cityu.edu.hk.
FAU - Cheng, Shuk Han
AU  - Cheng SH
AD  - Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, 
      China. bhcheng@cityu.edu.hk.
AD  - State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong 
      Kong, China. bhcheng@cityu.edu.hk.
FAU - Yu, Kwan Ngok
AU  - Yu KN
AD  - Department of Physics and Materials Science, City University of Hong Kong, Hong 
      Kong, China. peter.yu@cityu.edu.hk.
AD  - State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong 
      Kong, China. peter.yu@cityu.edu.hk.
LA  - eng
PT  - Journal Article
DEP - 20170211
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - *Alpha Particles
MH  - Animals
MH  - Apoptosis/radiation effects
MH  - Embryo, Nonmammalian/*radiation effects
MH  - *Hormesis
MH  - *Photons
MH  - Radiation Dosage
MH  - Radiation, Ionizing
MH  - X-Rays
MH  - *Zebrafish
PMC - PMC5343920
OTO - NOTNLM
OT  - ionizing radiation
OT  - photon hormesis
OT  - zebrafish embryos
COIS- The authors declare no conflict of interest.
EDAT- 2017/02/18 06:00
MHDA- 2017/04/30 06:00
PMCR- 2017/02/01
CRDT- 2017/02/18 06:00
PHST- 2016/12/09 00:00 [received]
PHST- 2017/02/03 00:00 [revised]
PHST- 2017/02/08 00:00 [accepted]
PHST- 2017/02/18 06:00 [entrez]
PHST- 2017/02/18 06:00 [pubmed]
PHST- 2017/04/30 06:00 [medline]
PHST- 2017/02/01 00:00 [pmc-release]
AID - ijms18020385 [pii]
AID - ijms-18-00385 [pii]
AID - 10.3390/ijms18020385 [doi]
PST - epublish
SO  - Int J Mol Sci. 2017 Feb 11;18(2):385. doi: 10.3390/ijms18020385.