PMID- 28210802
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20200330
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 27
IP  - 9
DP  - 2017 Sep
TI  - Poorly-differentiated colorectal neuroendocrine tumour: CT differentiation from 
      well-differentiated neuroendocrine tumour and poorly-differentiated 
      adenocarcinomas.
PG  - 3867-3876
LID - 10.1007/s00330-017-4764-5 [doi]
AB  - OBJECTIVE: The differentiation of poorly-differentiated neuroendocrine tumours 
      (PD-NETs), well-differentiated NETs (WD-NETs), and adenocarcinomas (ADCs) is 
      important due to different management options and prognoses. This study is to 
      find the differential CT features of colorectal PD-NETs from WD-NETs and ADCs. 
      MATERIALS AND METHODS: CT features of 25 colorectal WD-NETs, 36 PD-NETs, and 36 
      ADCs were retrospectively reviewed. Significant variables were assessed using 
      univariate and multivariate analyses. Receiver operating characteristics analysis 
      determined the optimal cut-off value of tumour and lymph node (LN) size. RESULTS: 
      Large size, rectum location, ulceroinfiltrative morphology without intact 
      overlying mucosa, heterogeneous attenuation with necrosis, presence of >/=3 
      enlarged LNs, and metastasis were significant variables to differentiate PD-NETs 
      from WD-NETs (P < 0.05). High attenuation on arterial phase, persistently high 
      enhancement pattern, presence of >/=6 enlarged LNs, large LN size, and 
      wash-in/wash-out enhancement pattern of liver metastasis were significant 
      variables to differentiate PD-NETs from ADCs (P < 0.05). CONCLUSIONS: Compared to 
      WD-NETs, colorectal PD-NETs are usually large, heterogeneous, and 
      ulceroinfiltrative mass without intact overlying mucosa involving enlarged LNs 
      and metastasis. High attenuation on arterial phase, presence of enlarged LNs with 
      larger size and greater number, and wash-in/wash-out enhancement pattern of liver 
      metastasis can be useful CT discriminators of PD-NETs from ADCs. KEY POINTS: * 
      Compared to WD-NETs, PD-NETs more frequently accompany enlarged LNs and 
      metastases. * Metastatic LNs from PD-NETs are significantly larger than those 
      from ADCs. * Hepatic metastases from PD-NETs usually show early enhancement and 
      delayed washout.
FAU - Kang, Ji Hee
AU  - Kang JH
AD  - Department of Radiology, Seoul National University Hospital, 101 Daehangno, 
      Jongno-gu, Seoul, 03080, Korea.
FAU - Kim, Se Hyung
AU  - Kim SH
AD  - Department of Radiology, Seoul National University Hospital, 101 Daehangno, 
      Jongno-gu, Seoul, 03080, Korea. shkim7071@gmail.com.
AD  - Department of Radiology, Seoul National University College of Medicine, 101 
      Daehangno, Jongno-gu, Seoul, 03080, Korea. shkim7071@gmail.com.
FAU - Han, Joon Koo
AU  - Han JK
AD  - Department of Radiology, Seoul National University Hospital, 101 Daehangno, 
      Jongno-gu, Seoul, 03080, Korea.
AD  - Department of Radiology, Seoul National University College of Medicine, 101 
      Daehangno, Jongno-gu, Seoul, 03080, Korea.
AD  - Institute of Radiation Medicine, Seoul National University Medical Research 
      Center, Seoul, Korea.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170216
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adenocarcinoma/*diagnostic imaging/pathology
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cell Transformation, Neoplastic
MH  - Colorectal Neoplasms/*diagnostic imaging/pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/diagnostic imaging/secondary
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/*diagnostic imaging/secondary
MH  - Prognosis
MH  - ROC Curve
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/methods
OTO - NOTNLM
OT  - Adenocarcinoma
OT  - CT
OT  - Colorectum
OT  - Differentiation
OT  - Neuroendocrine tumour
EDAT- 2017/02/18 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/02/18 06:00
PHST- 2016/06/20 00:00 [received]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2016/10/31 00:00 [revised]
PHST- 2017/02/18 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/02/18 06:00 [entrez]
AID - 10.1007/s00330-017-4764-5 [pii]
AID - 10.1007/s00330-017-4764-5 [doi]
PST - ppublish
SO  - Eur Radiol. 2017 Sep;27(9):3867-3876. doi: 10.1007/s00330-017-4764-5. Epub 2017 
      Feb 16.