PMID- 28211542
OWN - NLM
STAT- MEDLINE
DCOM- 20181024
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
DP  - 2017 Feb 17
TI  - Identification of the core regulators of the HLA I-peptide binding process.
PG  - 42768
LID - 10.1038/srep42768 [doi]
LID - 42768
AB  - During the display of peptide/human leukocyte antigen (HLA) -I complex for 
      further immune recognition, the cleaved and transported antigenic peptides have 
      to bind to HLA-I protein and the binding affinity between peptide epitopes and 
      HLA proteins directly influences the immune recognition ability in human beings. 
      Key factors affecting the binding affinity during the generation, selection and 
      presentation processes of HLA-I complex have not yet been fully discovered. In 
      this study, a new method describing the HLA class I-peptide interactions was 
      proposed. Three hundred and forty features of HLA I proteins and peptide 
      sequences were utilized for analysis by four candidate algorithms, screening the 
      optimal classifier. Features derived from the optimal classifier were further 
      selected and systematically analyzed, revealing the core regulators. The results 
      validated the hypothesis that features of HLA I proteins and related peptides 
      simultaneously affect the binding process, though with discrepant redundancy. 
      Besides, the high relative ratio (16/20) of the amino acid composition features 
      suggests the unique role of sequence signatures for the binding processes. 
      Integrating biological, evolutionary and chemical features of both HLA I 
      molecules and peptides, this study may provide a new perspective of the 
      underlying mechanisms of HLA I-mediated immune reactions.
FAU - Zhang, Yu-Hang
AU  - Zhang YH
AD  - Institute of Health Sciences, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 
      200031, People's Republic of China.
FAU - Xing, Zhihao
AU  - Xing Z
AD  - Institute of Health Sciences, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 
      200031, People's Republic of China.
FAU - Liu, Chenglin
AU  - Liu C
AD  - School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai 
      200240, People's Republic of China.
FAU - Wang, ShaoPeng
AU  - Wang S
AD  - School of Life Sciences, Shanghai University, Shanghai 200444, People's Republic 
      of China.
FAU - Huang, Tao
AU  - Huang T
AD  - Institute of Health Sciences, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 
      200031, People's Republic of China.
FAU - Cai, Yu-Dong
AU  - Cai YD
AD  - School of Life Sciences, Shanghai University, Shanghai 200444, People's Republic 
      of China.
FAU - Kong, Xiangyin
AU  - Kong X
AD  - Institute of Health Sciences, Shanghai Institutes for Biological Sciences, 
      Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 
      200031, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170217
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Peptides)
SB  - IM
MH  - *Algorithms
MH  - Antibody Affinity
MH  - Epitopes/chemistry/immunology
MH  - Histocompatibility Antigens Class I/chemistry/*immunology
MH  - Humans
MH  - Peptides/chemistry/*immunology
MH  - Protein Binding
PMC - PMC5314381
COIS- The authors declare no competing financial interests.
EDAT- 2017/02/18 06:00
MHDA- 2018/10/26 06:00
PMCR- 2017/02/17
CRDT- 2017/02/18 06:00
PHST- 2016/11/01 00:00 [received]
PHST- 2017/01/13 00:00 [accepted]
PHST- 2017/02/18 06:00 [entrez]
PHST- 2017/02/18 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
PHST- 2017/02/17 00:00 [pmc-release]
AID - srep42768 [pii]
AID - 10.1038/srep42768 [doi]
PST - epublish
SO  - Sci Rep. 2017 Feb 17;7:42768. doi: 10.1038/srep42768.