PMID- 28212390
OWN - NLM
STAT- MEDLINE
DCOM- 20170814
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 2
DP  - 2017
TI  - Lack of effects of fish oil supplementation for 12 weeks on resting metabolic 
      rate and substrate oxidation in healthy young men: A randomized controlled trial.
PG  - e0172576
LID - 10.1371/journal.pone.0172576 [doi]
LID - e0172576
AB  - Fish oil (FO) has been shown to have beneficial effects in the body via 
      incorporation into the membranes of many tissues. It has been proposed that 
      omega-3 fatty acids in FO may increase whole body resting metabolic rate (RMR) 
      and fatty acid (FA) oxidation in human subjects, but the results to date are 
      equivocal. The purpose of this study was to investigate the effects of a 12 week 
      FO supplementation period on RMR and substrate oxidation, in comparison to an 
      olive oil (OO) control group, in young healthy males (n = 26; 22.8 +/- 2.6 yr). 
      Subjects were matched for age, RMR, physical activity, VO2max and body mass, and 
      were randomly separated into a group supplemented with either OO (3 g/d) or FO 
      containing 2 g/d eicosapentaenoic acid (EPA) and 1 g/d docosahexaenoic acid 
      (DHA). Participants visited the lab for RMR and substrate oxidation measurements 
      after an overnight fast (10-12 hr) at weeks 0, 6 and 12. Fasted blood samples 
      were taken at baseline and after 12 weeks of supplementation. There were 
      significant increases in the EPA (413%) and DHA (59%) levels in red blood cells 
      after FO supplementation, with no change of these fatty acids in the OO group. 
      RMR and substrate oxidation did not change after supplementation with OO or FO 
      after 6 and 12 weeks. Since there was no effect of supplementation on metabolic 
      measures, we pooled the two treatment groups to determine whether there was a 
      seasonal effect on RMR and substrate oxidation. During the winter season, there 
      was an increase in FA oxidation (36%) with a concomitant decrease (34%) in 
      carbohydrate (CHO) oxidation (p < 0.01), with no change in RMR. These measures 
      were unaffected during the summer season. In conclusion, FO supplementation had 
      no effect on RMR and substrate oxidation in healthy young males. Resting FA 
      oxidation was increased and CHO oxidation reduced over a 12 week period in the 
      winter, with no change in RMR. TRIAL REGISTRATION: ClinicalTrials.gov 
      NCT02092649.
FAU - Jannas-Vela, Sebastian
AU  - Jannas-Vela S
AD  - Department of Human Health and Nutritional Sciences, University of Guelph, 
      Guelph, Ontario, Canada.
FAU - Roke, Kaitlin
AU  - Roke K
AD  - Department of Human Health and Nutritional Sciences, University of Guelph, 
      Guelph, Ontario, Canada.
FAU - Boville, Stephanie
AU  - Boville S
AD  - Department of Human Health and Nutritional Sciences, University of Guelph, 
      Guelph, Ontario, Canada.
FAU - Mutch, David M
AU  - Mutch DM
AD  - Department of Human Health and Nutritional Sciences, University of Guelph, 
      Guelph, Ontario, Canada.
FAU - Spriet, Lawrence L
AU  - Spriet LL
AD  - Department of Human Health and Nutritional Sciences, University of Guelph, 
      Guelph, Ontario, Canada.
LA  - eng
SI  - ClinicalTrials.gov/NCT02092649
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170217
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Fatty Acids)
RN  - 0 (Fish Oils)
RN  - 0 (Olive Oil)
RN  - 25167-62-8 (Docosahexaenoic Acids)
RN  - AAN7QOV9EA (Eicosapentaenoic Acid)
SB  - IM
MH  - Adult
MH  - Basal Metabolism/*drug effects
MH  - Carbohydrate Metabolism/drug effects
MH  - Dietary Supplements
MH  - Docosahexaenoic Acids/blood/pharmacology
MH  - Eicosapentaenoic Acid/blood/pharmacology
MH  - Erythrocytes/drug effects/metabolism
MH  - Fatty Acids/blood
MH  - Fish Oils/*pharmacology
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Olive Oil/pharmacology
MH  - Oxidation-Reduction
MH  - Seasons
PMC - PMC5315390
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/02/18 06:00
MHDA- 2017/08/15 06:00
PMCR- 2017/02/17
CRDT- 2017/02/18 06:00
PHST- 2016/03/29 00:00 [received]
PHST- 2017/02/06 00:00 [accepted]
PHST- 2017/02/18 06:00 [entrez]
PHST- 2017/02/18 06:00 [pubmed]
PHST- 2017/08/15 06:00 [medline]
PHST- 2017/02/17 00:00 [pmc-release]
AID - PONE-D-16-11091 [pii]
AID - 10.1371/journal.pone.0172576 [doi]
PST - epublish
SO  - PLoS One. 2017 Feb 17;12(2):e0172576. doi: 10.1371/journal.pone.0172576. 
      eCollection 2017.