PMID- 28212431
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 2
DP  - 2017
TI  - Mediterranean dietary pattern and VEGF +405 G/C gene polymorphisms in patients 
      with metabolic syndrome: An aspect of gene-nutrient interaction.
PG  - e0171637
LID - 10.1371/journal.pone.0171637 [doi]
LID - e0171637
AB  - AIMS: To evaluate the relationship between Mediterranean dietary pattern, 
      anthropometric and metabolic biomarkers and vascular endothelial growth factor 
      (VEGF) +405 G/C gene polymorphism in patient with metabolic syndrome (Mets). 
      MATERIALS AND METHODS: In this study 150 patients with Mets and 50 healthy 
      subjects were enrolled. Dietary intakes were evaluated with a semi-quantitative 
      food-frequency questionnaire (FFQ) and Mediterranean dietary quality index 
      (Med-DQI) was assessed. Anthropometric assessments and blood pressure measurement 
      were performed. Biochemical assays including fasting serum glucose (FSG), matrix 
      metalloproteinase-3 (MMP-3), liver enzymes and lipid profiles were also assessed. 
      Polymorphism of +405 G/C VEGF gene was determined utilizing polymerase chain 
      reaction-restriction fragments length polymorphism (PCR-RFLP) method. RESULTS: 
      Serum high density lipoprotein-cholesterol (HDL-C) was significantly lower and 
      low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol 
      (TC) concentrations and FSG were significantly higher in metabolic syndrome 
      patients compared with control group (P < 0.05). Metabolic syndrome group with 
      high consumption of "cholesterol" had significantly upper serum TG; also high 
      consumption of "fish" and "vegetables-fruits" was associated with a significantly 
      lower serum LDL concentrations. In metabolic syndrome patients with CC genotype, 
      mean score of "saturated fatty acid" subgroup was significantly higher compared 
      with other genotypes; whereas, in healthy individuals, mean score of 
      "fruit-vegetable" subgroup in individuals of CC and GG genotype was significantly 
      higher (P<0.05). CONCLUSION: Our findings indicated a significant relationship 
      between Mediterranean dietary quality index and both anthropometric and metabolic 
      risk factors. We also indicated a higher "saturated fatty acid" intake in CC 
      genotype among metabolic syndrome patients.
FAU - Hajiluian, Ghazaleh
AU  - Hajiluian G
AD  - Student Research Committee, Nutrition Research Center, Faculty of Nutrition, 
      Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Abbasalizad Farhangi, Mahdieh
AU  - Abbasalizad Farhangi M
AD  - Nutrition Research Center, Drug Applied Research Center, Department of Community 
      Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Jahangiry, Leila
AU  - Jahangiry L
AD  - Health Education and Health Promotion Department, School of Public Health, Tabriz 
      University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170217
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - *Diet, Mediterranean
MH  - Female
MH  - *Gene-Environment Interaction
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*genetics
MH  - *Polymorphism, Genetic
MH  - Vascular Endothelial Growth Factor A/*genetics
PMC - PMC5315280
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/02/18 06:00
MHDA- 2017/08/19 06:00
PMCR- 2017/02/17
CRDT- 2017/02/18 06:00
PHST- 2016/09/21 00:00 [received]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/02/18 06:00 [entrez]
PHST- 2017/02/18 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
PHST- 2017/02/17 00:00 [pmc-release]
AID - PONE-D-16-37844 [pii]
AID - 10.1371/journal.pone.0171637 [doi]
PST - epublish
SO  - PLoS One. 2017 Feb 17;12(2):e0171637. doi: 10.1371/journal.pone.0171637. 
      eCollection 2017.