PMID- 28212942
OWN - NLM
STAT- MEDLINE
DCOM- 20171213
LR  - 20180104
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 324
DP  - 2017 May 1
TI  - Activation of type 4 dopaminergic receptors in the prelimbic area of medial 
      prefrontal cortex is necessary for the expression of innate fear behavior.
PG  - 130-137
LID - S0166-4328(16)30858-0 [pii]
LID - 10.1016/j.bbr.2017.01.050 [doi]
AB  - The prelimbic area (PL) of the medial Prefrontal cortex (mPFC) is involved in the 
      acquisition and expression of conditioned and innate fear. Both types of fear 
      share several neuronal pathways. It has been documented that dopamine (DA) plays 
      an important role in the regulation of aversive memories in the mPFC. The 
      exposure to an aversive stimulus, such as the smell of a predator odor or the 
      exposure to footshock stress is accompanied by an increase in mPFC DA release. 
      Evidence suggests that the type 4 dopaminergic receptor (D4R) is the molecular 
      target through which DA modulates fear expression. In fact, the mPFC is the brain 
      region with the highest expression of D4R; however, the role of D4R in the 
      expression of innate fear has not been fully elucidated. Therefore, the principal 
      objective of this work was to evaluate the participation of mPFC D4R in the 
      expression of innate fear. Rats were exposed to the elevated plus-maze (EPM) and 
      to the cat odor paradigm after the intra PL injection of L-745,870, selective D4R 
      antagonist, to measure the expression of fear-related behaviors. Intra PL 
      injection of L-745,870 increased the time spent in the EPM open arms and 
      decreased freezing behavior in the cat odor paradigm. Our results also showed 
      that D4R is expressed in GABAergic and pyramidal neurons in the PL region of PFC. 
      Thus, D4R antagonism in the PL decreases the expression of innate fear-behavior 
      indicating that the activation of D4R in the PL is necessary for the expression 
      of innate fear-behavior.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Vergara, Macarena D
AU  - Vergara MD
AD  - Department of Cellular and Molecular Biology, Faculty of Biological Sciences, 
      Pontificia Universidad Catolica de Chile, Santiago, Chile.
FAU - Keller, Victor N
AU  - Keller VN
AD  - Department of Cellular and Molecular Biology, Faculty of Biological Sciences, 
      Pontificia Universidad Catolica de Chile, Santiago, Chile.
FAU - Fuentealba, Jose A
AU  - Fuentealba JA
AD  - Department of Pharmacy, Faculty of Chemistry, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile. Electronic address: jfuentea@uc.cl.
FAU - Gysling, Katia
AU  - Gysling K
AD  - Department of Cellular and Molecular Biology, Faculty of Biological Sciences, 
      Pontificia Universidad Catolica de Chile, Santiago, Chile. Electronic address: 
      kgysling@bio.puc.cl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170216
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Pyridines)
RN  - 0 (Pyrroles)
RN  - 137750-34-6 (Receptors, Dopamine D4)
SB  - IM
MH  - Animals
MH  - Anxiety/physiopathology
MH  - Avoidance Learning/drug effects/physiology
MH  - Dopamine Antagonists/administration & dosage
MH  - Fear/drug effects/*physiology
MH  - GABAergic Neurons/metabolism
MH  - Male
MH  - Odorants
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Pyramidal Cells/metabolism
MH  - Pyridines/administration & dosage
MH  - Pyrroles/administration & dosage
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D4/antagonists & inhibitors/metabolism/*physiology
OTO - NOTNLM
OT  - Anxiety
OT  - Cat odor
OT  - Dopamine
OT  - Innate fear
OT  - Prefrontal cortex
EDAT- 2017/02/19 06:00
MHDA- 2017/12/14 06:00
CRDT- 2017/02/19 06:00
PHST- 2016/10/25 00:00 [received]
PHST- 2017/01/26 00:00 [revised]
PHST- 2017/01/30 00:00 [accepted]
PHST- 2017/02/19 06:00 [pubmed]
PHST- 2017/12/14 06:00 [medline]
PHST- 2017/02/19 06:00 [entrez]
AID - S0166-4328(16)30858-0 [pii]
AID - 10.1016/j.bbr.2017.01.050 [doi]
PST - ppublish
SO  - Behav Brain Res. 2017 May 1;324:130-137. doi: 10.1016/j.bbr.2017.01.050. Epub 
      2017 Feb 16.