PMID- 28214071
OWN - NLM
STAT- MEDLINE
DCOM- 20180212
LR  - 20220408
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 28
IP  - 5
DP  - 2017 May
TI  - Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation.
PG  - 388-397
LID - S1043-2760(17)30007-3 [pii]
LID - 10.1016/j.tem.2017.01.003 [doi]
AB  - Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin 
      (NGAL), is released by various cell types and is an attractive biomarker of 
      inflammation, ischemia, infection, and kidney damage. Both intestinal and 
      metabolic inflammation, as observed in obesity and related disorders, are 
      associated with increased LCN2 synthesis. While LCN2 in the intestinal tract 
      regulates the composition of the gut microbiota and shows anti-inflammatory 
      activities, it also exhibits proinflammatory activities in other experimental 
      settings. In animal models of metabolic inflammation, type 2 diabetes mellitus 
      (T2DM), or nonalcoholic steatohepatitis (NASH), increased LCN2 expression favors 
      inflammation via the recruitment of inflammatory cells, such as neutrophils, and 
      the induction of proinflammatory cytokines. A better understanding of this 
      crucial marker of innate immunity might pave the way for targeting this pathway 
      in future therapies.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Moschen, Alexander R
AU  - Moschen AR
AD  - Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology 
      and Christian Doppler Laboratory for Mucosal Immunology, Medical University 
      Innsbruck, Innsbruck, Austria.
FAU - Adolph, Timon E
AU  - Adolph TE
AD  - Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology 
      and Christian Doppler Laboratory for Mucosal Immunology, Medical University 
      Innsbruck, Innsbruck, Austria.
FAU - Gerner, Romana R
AU  - Gerner RR
AD  - Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology 
      and Christian Doppler Laboratory for Mucosal Immunology, Medical University 
      Innsbruck, Innsbruck, Austria.
FAU - Wieser, Verena
AU  - Wieser V
AD  - Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology 
      and Christian Doppler Laboratory for Mucosal Immunology, Medical University 
      Innsbruck, Innsbruck, Austria.
FAU - Tilg, Herbert
AU  - Tilg H
AD  - Department of Internal Medicine I, Gastroenterology, Hepatology & Endocrinology 
      and Christian Doppler Laboratory for Mucosal Immunology, Medical University 
      Innsbruck, Innsbruck, Austria. Electronic address: herbert.tilg@i-med.ac.at.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170215
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Cytokines)
RN  - 0 (Lipocalin-2)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - Diabetes Mellitus, Type 2/immunology/metabolism
MH  - Humans
MH  - Inflammation/*immunology/*metabolism
MH  - Intestinal Mucosa/*metabolism
MH  - Intestines/*immunology
MH  - Lipocalin-2/*metabolism
EDAT- 2017/02/19 06:00
MHDA- 2018/02/13 06:00
CRDT- 2017/02/19 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/01/16 00:00 [revised]
PHST- 2017/01/18 00:00 [accepted]
PHST- 2017/02/19 06:00 [pubmed]
PHST- 2018/02/13 06:00 [medline]
PHST- 2017/02/19 06:00 [entrez]
AID - S1043-2760(17)30007-3 [pii]
AID - 10.1016/j.tem.2017.01.003 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2017 May;28(5):388-397. doi: 10.1016/j.tem.2017.01.003. 
      Epub 2017 Feb 15.