PMID- 28214088
OWN - NLM
STAT- MEDLINE
DCOM- 20170523
LR  - 20181202
IS  - 1532-2653 (Electronic)
IS  - 0967-5868 (Linking)
VI  - 39
DP  - 2017 May
TI  - A case of seropositive autoimmune autonomic ganglionopathy with diffuse 
      esophageal spasm.
PG  - 90-92
LID - S0967-5868(16)31266-8 [pii]
LID - 10.1016/j.jocn.2017.01.027 [doi]
AB  - Autoimmune autonomic ganglionopathy (AAG) is an immune-mediated disorder that 
      leads to various autonomic failures associated with anti-ganglionic acetylcholine 
      receptor antibodies (anti-gAChR-Abs). Diffuse esophageal spasm (DES) is an 
      uncommon esophageal motility disorder. We herein report the case of a 68-year-old 
      woman with DES as a partial symptom of AAG. She presented with chronic esophageal 
      transit failure, constipation, and numbness of the hands and feet, Adie's pupil, 
      thermal hypoalgesia, and decreased deep tendon reflexes. Right sural nerve biopsy 
      showed significantly decreased numbers of small myelinated fibers. Barium 
      swallowing X-ray showed repetitive simultaneous contractions indicating DES in 
      the esophagus. Gastrointestinal endoscopy and CT image showed a dilated 
      esophageal lumen and liquid effusion. Simultaneously, serum anti-gAChR-alpha3-Ab 
      indicating AAG was detected. After pulse intravenous methylprednisolone (IVMP) 
      and intravenous immunoglobulin therapy (IVIg), the bolus progression and liquid 
      effusion improved, suggesting that DES is an important gastrointestinal symptom 
      of AAG.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Morimoto, Nobutoshi
AU  - Morimoto N
AD  - Department of Neurology, Kagawa Prefectural Central Hospital, Japan. Electronic 
      address: morinobu@cc.okayama-u.ac.jp.
FAU - Takahashi, Sakuma
AU  - Takahashi S
AD  - Department of Gastroenterology, Kagawa Prefectural Central Hospital, Japan.
FAU - Inaba, Tomoki
AU  - Inaba T
AD  - Department of Gastroenterology, Kagawa Prefectural Central Hospital, Japan.
FAU - Takamiya, Motonori
AU  - Takamiya M
AD  - Department of Neurology, Kagawa Prefectural Central Hospital, Japan.
FAU - Kageyama, Yasuhiko
AU  - Kageyama Y
AD  - Department of Neurology, Kagawa Prefectural Central Hospital, Japan.
FAU - Morimoto, Mizuki
AU  - Morimoto M
AD  - Department of Neurology, Kagawa Prefectural Central Hospital, Japan.
FAU - Takahashi, Yoshiaki
AU  - Takahashi Y
AD  - Department of Neurology, Kagawa Prefectural Central Hospital, Japan; Department 
      of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Science, 
      Okayama University, Japan.
FAU - Nishimura, Hirotake
AU  - Nishimura H
AD  - Department of Pathology, Kawasaki Medical School, Japan.
FAU - Nakane, Shunya
AU  - Nakane S
AD  - Department of Neurology, Graduate School of Medical Sciences, Kumamoto 
      University, Japan.
FAU - Abe, Koji
AU  - Abe K
AD  - Department of Neurology, Graduate School of Medicine, Dentistry and 
      Pharmaceutical Science, Okayama University, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20170214
PL  - Scotland
TA  - J Clin Neurosci
JT  - Journal of clinical neuroscience : official journal of the Neurosurgical Society 
      of Australasia
JID - 9433352
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Aged
MH  - Autoantibodies/blood
MH  - Autonomic Nervous System Diseases/blood/*complications/*diagnostic imaging
MH  - Esophageal Spasm, Diffuse/blood/*complications/*diagnostic imaging
MH  - Female
MH  - Ganglia, Autonomic/*diagnostic imaging
MH  - Humans
OTO - NOTNLM
OT  - Anti-ganglionic acetylcholine receptor alpha3 antibody
OT  - Autoimmune autonomic ganglionopathy (AAG)
OT  - Diffuse esophageal spasm (DES)
OT  - Intravenous immunoglobulin therapy (IVIg)
EDAT- 2017/02/19 06:00
MHDA- 2017/05/24 06:00
CRDT- 2017/02/19 06:00
PHST- 2016/11/16 00:00 [received]
PHST- 2017/01/22 00:00 [accepted]
PHST- 2017/02/19 06:00 [pubmed]
PHST- 2017/05/24 06:00 [medline]
PHST- 2017/02/19 06:00 [entrez]
AID - S0967-5868(16)31266-8 [pii]
AID - 10.1016/j.jocn.2017.01.027 [doi]
PST - ppublish
SO  - J Clin Neurosci. 2017 May;39:90-92. doi: 10.1016/j.jocn.2017.01.027. Epub 2017 
      Feb 14.