PMID- 28214177
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20180607
IS  - 1096-3618 (Electronic)
IS  - 1044-5323 (Linking)
VI  - 29
DP  - 2017 Feb
TI  - Dendritic cells in host response to biologic scaffolds.
PG  - 41-48
LID - S1044-5323(16)30083-5 [pii]
LID - 10.1016/j.smim.2017.01.001 [doi]
AB  - Tissue regeneration and repair require a highly complex and orchestrated series 
      of events that require inflammation, but can be compromised when inflammation is 
      excessive or becomes chronic. Macrophages are one of the first cells to contact 
      and respond to implanted materials, and mediate the inflammatory response. The 
      series of events following macrophage association with biomaterials has been 
      well-studied. Dendritic cells (DCs) also directly interact with biomaterials, are 
      critical for specific immune responses, and can be activated in response to 
      interactions with biomaterials. Yet, much less is known about the responses by 
      DCs. This review discusses what we know about DC response to biomaterials, the 
      underlying mechanisms involved, and how DCs can be influenced by the macrophage 
      response to biomaterials. Lastly, I will discuss how biomaterials can be 
      manipulated to enhance or suppress DC function to promote a specific desirable 
      immune response - a major goal for implantable biologically active therapeutics.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Leifer, Cynthia A
AU  - Leifer CA
AD  - Department of Microbiology and Immunology College of Veterinary Medicine, C5-153 
      Cornell University, Ithaca, NY, USA. Electronic address: 
      Cynthia.leifer@cornell.edu.
LA  - eng
GR  - R21 AI111081/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20170214
PL  - England
TA  - Semin Immunol
JT  - Seminars in immunology
JID - 9009458
RN  - 0 (Biocompatible Materials)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/*metabolism
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunomodulation
MH  - Macrophages/*immunology
MH  - Regenerative Medicine
MH  - *Tissue Engineering
MH  - *Tissue Scaffolds
OTO - NOTNLM
OT  - Immunomodulation
OT  - biomaterials
OT  - dendritic cell
OT  - extracellular matrix
OT  - innate immunity
OT  - macrophage
EDAT- 2017/02/19 06:00
MHDA- 2018/05/22 06:00
CRDT- 2017/02/19 06:00
PHST- 2016/08/23 00:00 [received]
PHST- 2017/01/23 00:00 [revised]
PHST- 2017/01/31 00:00 [accepted]
PHST- 2017/02/19 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2017/02/19 06:00 [entrez]
AID - S1044-5323(16)30083-5 [pii]
AID - 10.1016/j.smim.2017.01.001 [doi]
PST - ppublish
SO  - Semin Immunol. 2017 Feb;29:41-48. doi: 10.1016/j.smim.2017.01.001. Epub 2017 Feb 
      14.