PMID- 2821435
OWN - NLM
STAT- MEDLINE
DCOM- 19871029
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 26
IP  - 7B
DP  - 1987 Jul
TI  - Potentiators of responses to activation of gamma-aminobutyric acid (GABAA) 
      receptors.
PG  - 923-30
AB  - Quantitative aspects of the potentiation of GABA and muscimol by benzodiazepines 
      and barbiturates are reviewed, taking account of both electrophysiological and 
      receptor binding data. It has been a consistent finding that barbiturates cause a 
      greater maximal potentiation than do benzodiazepines. The steroid anaesthetic 
      alphaxalone and some naturally occurring steroids were compared as potentiators 
      of electrophysiological responses to muscimol. From the relative potencies, 
      important structural features of the steroid molecule for this effect have been 
      identified. The possibility of the barbiturates and the steroids having a common 
      mode of action as potentiators of GABA and muscimol is discussed, together with 
      the idea that this action may involve perturbation of membrane lipids rather than 
      a barbiturate/steroid receptor site. The GABA-potentiating effect of ethanol may 
      also be barbiturate-like but potentiations by chlormethiazole and ketamine appear 
      to involve different mechanisms. It is predicted that any endogenous potentiators 
      of GABA would be unlikely to have more than a modest effect.
FAU - Simmonds, M A
AU  - Simmonds MA
AD  - Department of Pharmacology, School of Pharmacy, University of London, Brunswick 
      Square, U.K.
FAU - Turner, J P
AU  - Turner JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Barbiturates)
RN  - 0 (Carbolines)
RN  - 0 (Chlorides)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Steroids)
RN  - 0C5DBZ19HV (Chlormethiazole)
RN  - 3K9958V90M (Ethanol)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Animals
MH  - Barbiturates/pharmacology
MH  - Carbolines/pharmacology
MH  - Chlorides/metabolism
MH  - Chlormethiazole/pharmacology
MH  - Ethanol/pharmacology
MH  - Ketamine/pharmacology
MH  - Receptors, GABA-A/*physiology
MH  - Steroids/pharmacology
MH  - gamma-Aminobutyric Acid/pharmacology
RF  - 54
EDAT- 1987/07/01 00:00
MHDA- 1987/07/01 00:01
CRDT- 1987/07/01 00:00
PHST- 1987/07/01 00:00 [pubmed]
PHST- 1987/07/01 00:01 [medline]
PHST- 1987/07/01 00:00 [entrez]
AID - 10.1016/0028-3908(87)90071-2 [doi]
PST - ppublish
SO  - Neuropharmacology. 1987 Jul;26(7B):923-30. doi: 10.1016/0028-3908(87)90071-2.