PMID- 28215176
OWN - NLM
STAT- MEDLINE
DCOM- 20180221
LR  - 20180221
IS  - 1875-6336 (Electronic)
IS  - 1573-3963 (Linking)
VI  - 13
IP  - 2
DP  - 2017
TI  - Comparison the Serum STREM1 Levels Between Children with Upper and Lower UTI.
PG  - 152-156
LID - 10.2174/1573396313666170216154528 [doi]
AB  - BACKGROUND: Pyelonephritis is the most common and important infection among 
      Iranian pediatric population. Differentiation between upper and lower Urinary 
      Tract Infection (UTI) is often difficult based on clinical data. Therefore, 
      definite diagnosis is helpful for choosing appropriate antibiotic and decision 
      for hospital admission. The main purpose of this study was todetermine the 
      diagnostic value of serum STREM-1 level in children suspicious to UTI and 
      differentiation of upper UTI and lower UTI. MATERIAL & METHODS: This prospective 
      cross sectional study (2010-2011) was performed to evaluate and compare the serum 
      level of STREM- 1 (pg. /ml) in 36 diagnosed UTI patients (24 upper and 12 lower 
      UTI) with 25 normal children (without UTI) in Rasoul Akram hospital, Tehran, 
      Iran. The mean age of studied children was 3.64 years; 24 male and 37 female. 
      Urinary analysis and urine culture were performed for all UTI cases and only the 
      positive cultured cases with the same microorganism were enrolled in the study. 
      Distinguishing the upper from lower UTI was done on the basis of clinical 
      manifestation and laboratory tests and confirmed by Imaging studies (ultra 
      sonography /or DMSA scan). Blood sampling was taken from all children and 
      centrifuged .The level of STREM-1 (pg /ml) in all sera was determined by Enzyme 
      immunoassay technique (Human TREM-1 immunoassay Sandwich test, Quantikine, R&D 
      systems, Minneapolis; USA). Cut-off levels for STREM-1 were illustrated by ROC 
      curve. The p<0.05 was considered as significant for differences between groups. 
      FINDINGS: The mean of STREM -1level had significant difference between overall 
      cases of UTI (427.72pg/ml) and controls (124.24 pg. /ml; P =0.000) ; with cutoff 
      point 111.5 pg./ml ; it had 83.3% sensitivity; and 60 % specificity to 
      distinguish UTI from control. Serum STREM -1 level had no significantly 
      difference between the upper and lower UTI (500pg/ml vs. 283 pg. /ml, P 
      value=0.1) with cutoff point 132 pg./ml it had 83.3% sensitivity ; and 60 % 
      specificity to distinguish upper UTI from lower UTI. CONCLUSION: Our study 
      demonstrates that even low amount of serum STREM-1 (111.5 pg./ml) has 83.3% 
      sensitivity ; and 60 % specificity to distinguish the UTI from normal cases (P 
      value =0.000) but higher level (132 pg./ml) was needed for definite diagnosis 
      (83.3% sensitivity; 60 % specificity) of upper and lower UTI. It is concluded 
      that serum STREM-1 level test is a valuable tool for early diagnosis of the 
      normal cases with false positive urine culture, or in highly suspicious upper UTI 
      cases with false negative urine culture. Indeed higher titer of this biomarker 
      could be helpful for discriminating the upper from lower UTI. Therefore adding 
      this new biologic marker (STREM-1) to previous ones (CRP, PCT) is suggested to 
      prevent the unnecessary hospital admission and empiric antibiotic therapy.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Ehsanipour, Fahime
AU  - Ehsanipour F
AD  - Pediatric Infectious Diseases Department, Iran University of Medical Sciences, 
      Tehran. Iran.
FAU - Noorbakhsh, Samileh
AU  - Noorbakhsh S
AD  - Pediatric Infectious Diseases Department, Iran University of Medical Sciences, 
      Tehran. Iran.
FAU - Zarabi, Vida
AU  - Zarabi V
AD  - Pediatric Infectious Diseases Department, Iran University of Medical Sciences, 
      Tehran. Iran.
FAU - Movahedi, Zahra
AU  - Movahedi Z
AD  - Pediatric Infectious Diseases Department, Iran University of Medical Sciences, 
      Tehran. Iran.
FAU - Rahimzadeh, Nahid
AU  - Rahimzadeh N
AD  - Pediatric Infectious Diseases Department, Qom University of Medical Sciences and 
      health services, Qom. Iran.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Pediatr Rev
JT  - Current pediatric reviews
JID - 101240290
RN  - 0 (Biomarkers)
RN  - 0 (TREM1 protein, human)
RN  - 0 (Triggering Receptor Expressed on Myeloid Cells-1)
SB  - IM
MH  - Biomarkers/*blood
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Iran
MH  - Male
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Triggering Receptor Expressed on Myeloid Cells-1/*blood
MH  - Urinary Tract Infections/*blood/diagnosis
OTO - NOTNLM
OT  - STREM-1
OT  - biologic marker
OT  - children
OT  - serum
OT  - specificity
OT  - upper and lower UTI
EDAT- 2017/02/22 06:00
MHDA- 2018/02/22 06:00
CRDT- 2017/02/21 06:00
PHST- 2016/02/05 00:00 [received]
PHST- 2017/01/06 00:00 [revised]
PHST- 2017/02/08 00:00 [accepted]
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2018/02/22 06:00 [medline]
PHST- 2017/02/21 06:00 [entrez]
AID - CPR-EPUB-81830 [pii]
AID - 10.2174/1573396313666170216154528 [doi]
PST - ppublish
SO  - Curr Pediatr Rev. 2017;13(2):152-156. doi: 10.2174/1573396313666170216154528.