PMID- 28215181 OWN - NLM STAT- MEDLINE DCOM- 20171212 LR - 20240117 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 19 IP - 1 DP - 2017 Feb 20 TI - Effect of cellular and extracellular pathology assessed by T1 mapping on regional contractile function in hypertrophic cardiomyopathy. PG - 16 LID - 10.1186/s12968-017-0334-x [doi] LID - 16 AB - BACKGROUND: Regional contractile dysfunction is a frequent finding in hypertrophic cardiomyopathy (HCM). We aimed to investigate the contribution of different tissue characteristics in HCM to regional contractile dysfunction. METHODS: We prospectively recruited 50 patients with HCM who underwent cardiovascular magnetic resonance (CMR) studies at 3.0 T including cine imaging, T1 mapping and late gadolinium enhancement (LGE) imaging. For each segment of the American Heart Association model segment thickness, native T1, extracellular volume (ECV), presence of LGE and regional strain (by feature tracking and tissue tagging) were assessed. The relationship of segmental function, hypertrophy and tissue characteristics were determined using a mixed effects model, with random intercept for each patient. RESULTS: Individually segment thickness, native T1, ECV and the presence of LGE all had significant associations with regional strain. The first multivariable model (segment thickness, LGE and ECV) demonstrated that all strain parameters were associated with segment thickness (P < 0.001 for all) but not ECV. LGE (Beta 2.603, P = 0.024) had a significant association with circumferential strain measured by tissue tagging. In a second multivariable model (segment thickness, LGE and native T1) all strain parameters were associated with both segment thickness (P < 0.001 for all) and native T1 (P < 0.001 for all) but not LGE. CONCLUSION: Impairment of contractile function in HCM is predominantly associated with the degree of hypertrophy and native T1 but not markers of extracellular fibrosis (ECV or LGE). These findings suggest that impairment of contractility in HCM is mediated by mechanisms other than extracellular expansion that include cellular changes in structure and function. The cellular mechanisms leading to increased native T1 and its prognostic significance remain to be established. FAU - Swoboda, Peter P AU - Swoboda PP AUID- ORCID: 0000-0001-7162-7079 AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. p.swoboda@leeds.ac.uk. FAU - McDiarmid, Adam K AU - McDiarmid AK AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Erhayiem, Bara AU - Erhayiem B AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Law, Graham R AU - Law GR AD - Division of Epidemiology and Biostatistics, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK. FAU - Garg, Pankaj AU - Garg P AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Broadbent, David A AU - Broadbent DA AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. AD - Department of Medical Physics and Engineering, Leeds Teaching Hospitals NHS Trust, Leeds, UK. FAU - Ripley, David P AU - Ripley DP AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Musa, Tarique A AU - Musa TA AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Dobson, Laura E AU - Dobson LE AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Foley, James R AU - Foley JR AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Fent, Graham J AU - Fent GJ AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Page, Stephen P AU - Page SP AD - Inherited Cardiovascular Conditions Service, Leeds General Infirmary, Leeds, LS1 3EX, UK. FAU - Greenwood, John P AU - Greenwood JP AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. FAU - Plein, Sven AU - Plein S AD - Multidisciplinary Cardiovascular Research Centre (MCRC) & Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK. LA - eng GR - FS/12/88/29901/BHF_/British Heart Foundation/United Kingdom GR - PG/14/10/30641/BHF_/British Heart Foundation/United Kingdom GR - RG/16/1/32092/BHF_/British Heart Foundation/United Kingdom PT - Journal Article DEP - 20170220 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Adult MH - Biomechanical Phenomena MH - Cardiomyopathy, Hypertrophic/*diagnostic imaging/pathology/physiopathology MH - Case-Control Studies MH - Contrast Media/administration & dosage MH - Female MH - Fibrosis MH - Humans MH - Image Interpretation, Computer-Assisted/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Multivariate Analysis MH - *Myocardial Contraction MH - Myocardium/*pathology MH - Organometallic Compounds/administration & dosage MH - Predictive Value of Tests MH - Prospective Studies MH - Stress, Mechanical MH - Stroke Volume MH - *Ventricular Function, Left MH - Ventricular Remodeling PMC - PMC5317053 OTO - NOTNLM OT - Extracellular volume OT - Feature tracking OT - Hypertrophic cardiomyopathy OT - Strain OT - T1 mapping OT - Tissue tagging EDAT- 2017/02/22 06:00 MHDA- 2017/12/13 06:00 PMCR- 2017/02/20 CRDT- 2017/02/21 06:00 PHST- 2017/01/10 00:00 [received] PHST- 2017/01/27 00:00 [accepted] PHST- 2017/02/21 06:00 [entrez] PHST- 2017/02/22 06:00 [pubmed] PHST- 2017/12/13 06:00 [medline] PHST- 2017/02/20 00:00 [pmc-release] AID - S1097-6647(23)01050-5 [pii] AID - 334 [pii] AID - 10.1186/s12968-017-0334-x [doi] PST - epublish SO - J Cardiovasc Magn Reson. 2017 Feb 20;19(1):16. doi: 10.1186/s12968-017-0334-x.