PMID- 28216266
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20180421
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 69
DP  - 2017 Apr
TI  - Perinatal administration of bisphenol A alters the expression of tight junction 
      proteins in the uterus and reduces the implantation rate.
PG  - 106-120
LID - S0890-6238(17)30088-6 [pii]
LID - 10.1016/j.reprotox.2017.02.009 [doi]
AB  - We studied the effect of bisphenol-A (BPA) administration to rats, during the 
      perinatal period, on the fertility of F1 generation and on the expression of 
      tight junction (TJ) proteins in the uterus during early pregnancy. Pregnant 
      Wistar dams (F0) received: BPA-L (0.05mg/kg/day), BPA-H (20mg/kg/day) or vehicle, 
      from gestational day (GD) 6 to lactation day 21. F1 female pups were mated at 3 
      months of age and sacrificed at GD 1, 3, 6, and 7. Serum hormonal levels, 
      ovulation rate, number of implantation sites and expression of TJ proteins in the 
      uterus of F1 females were evaluated. BPA treatment induced no change in ovulation 
      rate, but induced alterations in progesterone (P(4)) and estradiol (E(2)) serum 
      levels, and in implantation rate. With regards to TJ proteins, BPA-H increased 
      claudin-1 during all GDs; eliminated the peaks of claudins -3 and -4 at GD 3 and 
      6, respectively; and decreased claudin-7 at GD 6, ZO-1 from GD 1-6, and claudin-3 
      at GD 7 in stromal cells. BPA-L instead, eliminated claudin-3 peak at GD 3, 
      increased claudin-4 and decreased claudin-7 from GD 1-6, decreased claudin-1 at 
      GD 3 and 7 and claudin-4 at GD 7 in stromal cells. BPA-L also decreased ZO-1 at 
      GDs 1 and 3 and increased ZO-1 at GD 6. Thus, BPA treatment during perinatal 
      period perturbed, when the animals reached adulthood and became pregnant, the 
      particular expression of TJ proteins in the uterine epithelium and reduced in 
      consequence the number of implantation sites.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Martinez-Pena, Annia A
AU  - Martinez-Pena AA
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Mexico D.F. 04510, Mexico.
FAU - Rivera-Banos, Jorge
AU  - Rivera-Banos J
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Mexico D.F. 04510, Mexico.
FAU - Mendez-Carrillo, Laura L
AU  - Mendez-Carrillo LL
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Mexico D.F. 04510, Mexico.
FAU - Ramirez-Solano, Marcos I
AU  - Ramirez-Solano MI
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Mexico D.F. 04510, Mexico.
FAU - Galindo-Bustamante, Aaron
AU  - Galindo-Bustamante A
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Mexico D.F. 04510, Mexico.
FAU - Paez-Franco, J Carlos
AU  - Paez-Franco JC
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Mexico D.F. 04510, Mexico.
FAU - Morimoto, Sumiko
AU  - Morimoto S
AD  - Instituto Nacional de Ciencias Medicas y de la Nutricion Salvador Zubiran, 
      Mexico, D.F. 14080, Mexico.
FAU - Gonzalez-Mariscal, Lorenza
AU  - Gonzalez-Mariscal L
AD  - Centro de Investigacion y Estudios Avanzados (CINVESTAV), Departamento de 
      Fisiologia, Biofisica y Neurociencias, Mexico, D.F. 07360, Mexico.
FAU - Cruz, M Esther
AU  - Cruz ME
AD  - Facultad de Estudios Superiores Zaragoza, Laboratorio de Neuroendocrinologia, 
      Universidad Nacional Autonoma de Mexico, Mexico, D.F. 15000, Mexico.
FAU - Mendoza-Rodriguez, C Adriana
AU  - Mendoza-Rodriguez CA
AD  - Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de 
      Mexico, Mexico D.F. 04510, Mexico. Electronic address: adrimed@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170217
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phenols)
RN  - 0 (Tight Junction Proteins)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Animals
MH  - Benzhydryl Compounds/*toxicity
MH  - Embryo Implantation/drug effects
MH  - Endocrine Disruptors/*toxicity
MH  - Estradiol/blood
MH  - Female
MH  - Lactation
MH  - Male
MH  - Phenols/*toxicity
MH  - Pregnancy
MH  - Progesterone/blood
MH  - Rats, Wistar
MH  - Tight Junction Proteins/*metabolism
MH  - Uterus/*drug effects/metabolism
OTO - NOTNLM
OT  - Bisphenol-A
OT  - Claudins
OT  - Implantation
OT  - Tight junctions
OT  - ZO-1
EDAT- 2017/02/22 06:00
MHDA- 2018/02/21 06:00
CRDT- 2017/02/21 06:00
PHST- 2016/07/21 00:00 [received]
PHST- 2017/02/07 00:00 [revised]
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2017/02/21 06:00 [entrez]
AID - S0890-6238(17)30088-6 [pii]
AID - 10.1016/j.reprotox.2017.02.009 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2017 Apr;69:106-120. doi: 10.1016/j.reprotox.2017.02.009. Epub 
      2017 Feb 17.