PMID- 28217287
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2041-9414 (Print)
IS  - 2041-9414 (Electronic)
IS  - 2041-9414 (Linking)
VI  - 7
DP  - 2016
TI  - Strong Correlation among Three Biodosimetry Techniques Following Exposures to 
      Ionizing Radiation.
PG  - 11
LID - 10.4103/2041-9414.197168 [doi]
LID - 11
AB  - Three in vitro dose calibration curves for biodosimetry such as dicentric 
      chromosome assay, fluorescence in situ hybridization (FISH) assay for 
      translocation, and micronuclei (MNs) in binucleated cell assay were established 
      after exposure to ionizing radiation. Peripheral blood lymphocyte samples 
      obtained from healthy donors were irradiated with (60)Co source at a dose rate of 
      0.5 Gy/min to doses of 0.1-6 Gy. The results from three in vitro dose calibration 
      curves for biodosimetry were analyzed to understand the relationship among 
      biodosimetry assay techniques. Our comparison demonstrates that there is a very 
      strong positive correlation among the dicentric assay, FISH, and MNs analysis, 
      and these three biodosimetry assays strongly support the in vitro dose 
      reconstruction and the emergency preparedness of public or occupational radiation 
      overexposure.
FAU - Kang, Chang-Mo
AU  - Kang CM
AD  - Division of Radiation Effect, Korea Institute of Radiological and Medical 
      Sciences, Seoul 01812, Republic of Korea.
FAU - Yun, Hyun Jin
AU  - Yun HJ
AD  - Division of Radiation Effect, Korea Institute of Radiological and Medical 
      Sciences, Seoul 01812, Republic of Korea.
FAU - Kim, Hanna
AU  - Kim H
AD  - Radiation Epidemiology Team, Radiation Health Institute, Korea Hydro and Nuclear 
      Power Co., Gyeonggi-do 13605, Republic of Korea.
FAU - Kim, Cha Soon
AU  - Kim CS
AD  - Radiation Epidemiology Team, Radiation Health Institute, Korea Hydro and Nuclear 
      Power Co., Gyeonggi-do 13605, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20161230
PL  - United States
TA  - Genome Integr
JT  - Genome integrity
JID - 101534214
PMC - PMC5292912
OTO - NOTNLM
OT  - Dicentric assay
OT  - fluorescence in situ hybridization
OT  - ionizing radiation
OT  - micronucleus assay
OT  - translocations
COIS- There are no conflicts of interest.
EDAT- 2017/02/22 06:00
MHDA- 2017/02/22 06:01
PMCR- 2016/12/30
CRDT- 2017/02/21 06:00
PHST- 2017/02/21 06:00 [entrez]
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2017/02/22 06:01 [medline]
PHST- 2016/12/30 00:00 [pmc-release]
AID - GI-7-11 [pii]
AID - 10.4103/2041-9414.197168 [doi]
PST - epublish
SO  - Genome Integr. 2016 Dec 30;7:11. doi: 10.4103/2041-9414.197168. eCollection 2016.