PMID- 28217523 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2230-8210 (Print) IS - 2230-9500 (Electronic) IS - 2230-9500 (Linking) VI - 21 IP - 1 DP - 2017 Jan-Feb TI - Safe and pragmatic use of sodium-glucose co-transporter 2 inhibitors in type 2 diabetes mellitus: South Asian Federation of Endocrine Societies consensus statement. PG - 210-230 LID - 10.4103/2230-8210.196029 [doi] AB - Diabetes prevalence shows a continuous increasing trend in South Asia. Although well-established treatment modalities exist for type 2 diabetes mellitus (T2DM) management, they are limited by their side effect profile. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) with their novel insulin-independent renal action provide improved glycemic control, supplemented by reduction in weight and blood pressure, and cardiovascular safety. Based on the clinical outcomes with SGLT2i in patients with T2DM, treatment strategies that make a "good clinical sense" are desirable. Considering the peculiar lifestyle, body types, dietary patterns (long duration religious fasts), and the hot climate of the South Asian population, a unanimous decision was taken to design specific, customized guidelines for T2DM treatment strategies in these regions. The panel met for a discussion three times so as to get a consensus for the guidelines, and only unanimous consensus was included. After careful consideration of the quality and strength of the available evidence, the executive summary of this consensus statement was developed based on the American Association of Clinical Endocrinologists/American College of Endocrinology protocol. FAU - Kalra, Sanjay AU - Kalra S AD - Department of Endocrinology, Bharti Hospital, Karnal, Haryana, India. FAU - Ghosh, Sujoy AU - Ghosh S AD - Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India. FAU - Aamir, A H AU - Aamir AH AD - Department of Endocrinology and Metabolic Diseases, Post Graduate Medical Institute, Hayatabad Medical Complex, Peshawar, Pakistan. FAU - Ahmed, Md Tofail AU - Ahmed MT AD - Department of Endocrinology, BIRDEM and Ibrahim Medical College, Dhaka, Bangladesh. FAU - Amin, Mohammod Feroz AU - Amin MF AD - Department of Endocrinology, BIRDEM and Ibrahim Medical College, Dhaka, Bangladesh. FAU - Bajaj, Sarita AU - Bajaj S AD - Department of Medicine, MLN Medical College, Allahabad, Uttar Pradesh, India. FAU - Baruah, Manash P AU - Baruah MP AD - Department of Endocrinology, Excel Centre Hospitals, Guwahati, Assam, India. FAU - Bulugahapitiya, Uditha AU - Bulugahapitiya U AD - Department of Endocrinology, Colombo South Teaching Hospital, Colombo, Sri Lanka. FAU - Das, A K AU - Das AK AD - Department of Medicine, Pondicherry Institute of Medical Sciences, Puducherry, India. FAU - Giri, Mimi AU - Giri M AD - BP Koirala Institute of Health Sciences, Dharan, Nepal. FAU - Gunatilake, Sonali AU - Gunatilake S AD - Department of Endocrinology, Colombo South Teaching Hospital, Colombo, Sri Lanka. FAU - Mahar, Saeed A AU - Mahar SA AD - Department of Medicine, National Institute of Cardiovascular Diseases, Karachi, Pakistan. FAU - Pathan, Md Faruque AU - Pathan MF AD - Department of Endocrinology, BIRDEM and Ibrahim Medical College, Dhaka, Bangladesh. FAU - Qureshi, Nazmul Kabir AU - Qureshi NK AD - Department of Endocrinology, Asgar Ali Hospital, Dhaka, Bangladesh. FAU - Raza, S Abbas AU - Raza SA AD - Department of Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. FAU - Sahay, Rakesh AU - Sahay R AD - Department of Endocrinology, Osmania Medical College, Hyderabad, Telangana, India. FAU - Shakya, Santosh AU - Shakya S AD - Diabetes, Thyroid and Endocrinology Care Centre, Kopundole, Nepal. FAU - Shreshta, Dina AU - Shreshta D AD - Department of Endocrinology, Norvic Hospital, Kathmandu, Nepal. FAU - Somasundaram, Noel AU - Somasundaram N AD - Department of Endocrinology, National Hospital of Sri Lanka, Colombo, Sri Lanka. FAU - Sumanatilleke, Manilka AU - Sumanatilleke M AD - Department of Endocrinology, Teaching Hospital Karapitiya, Galle, Sri Lanka. FAU - Unnikrishnan, A G AU - Unnikrishnan AG AD - Department of Endocrinology, Chellaram Institute of Diabetes, Pune, Maharashtra, India. FAU - Wijesinghe, Achini Madushani AU - Wijesinghe AM AD - Department of Endocrinology, National Hospital of Sri Lanka, Colombo, Sri Lanka. LA - eng PT - Journal Article PT - Review PL - India TA - Indian J Endocrinol Metab JT - Indian journal of endocrinology and metabolism JID - 101555690 PMC - PMC5240067 OTO - NOTNLM OT - Canagliflozin OT - South Asia OT - dapagliflozin OT - diabetes mellitus OT - empagliflozin OT - glycosuria OT - hyperglycemia OT - sodium-glucose co-transporter 2 COIS- There are no conflicts of interest. EDAT- 2017/02/22 06:00 MHDA- 2017/02/22 06:01 PMCR- 2017/01/01 CRDT- 2017/02/21 06:00 PHST- 2017/02/21 06:00 [entrez] PHST- 2017/02/22 06:00 [pubmed] PHST- 2017/02/22 06:01 [medline] PHST- 2017/01/01 00:00 [pmc-release] AID - IJEM-21-210 [pii] AID - 10.4103/2230-8210.196029 [doi] PST - ppublish SO - Indian J Endocrinol Metab. 2017 Jan-Feb;21(1):210-230. doi: 10.4103/2230-8210.196029.