PMID- 28217986
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20170911
IS  - 1827-1669 (Electronic)
IS  - 0026-4806 (Linking)
VI  - 108
IP  - 4
DP  - 2017 Aug
TI  - The effects of remote ischemic conditioning in patients with ST-segment elevation 
      myocardial infarction treated with primary percutaneous coronary intervention: a 
      meta-analysis.
PG  - 370-380
LID - 10.23736/S0026-4806.17.04631-6 [doi]
AB  - INTRODUCTION: Timely and successful reperfusion is effective at improving outcome 
      in patients presenting with ST elevation myocardial infarction (STEMI). However, 
      abrupt restoration of blood flow may cause detrimental myocardial reperfusion 
      injury. Remote ischemic conditioning (RIC) is a potent activator of innate 
      protection against ischemia-reperfusion injury. This study assessed remote 
      ischemic conditioning in patients presenting with STEMI treated with primary 
      percutaneous coronary intervention (PCI). EVIDENCE ACQUISITION: Relevant studies 
      were identified through electronic literature search from PubMed, Medline, 
      EMBASE, CNKI, WANFANG, and VIP. Studies published up to December 2015 were 
      eligible for inclusion. RIC was performed by applying consecutive cycles of 
      reocclusion/reperfusion through intermittent upper or lower limb ischemia before, 
      during, or after reperfusion. The outcomes included creatine kinase-MB (CK-MB), 
      ST resolution (STR), and left ventricular ejection fraction (LVEF). EVIDENCE 
      SYNTHESIS: The 9 trials allocated 540 patients to perform RIC cycles before, 
      during, or after reperfusion and 533 patients to usual PCI. Statistical analysis 
      indicated that the peak of CK-MB and CK-MB AUC in RIC groups decrease 
      significantly during the first 72 hours after PCI compared with controls (P=0.02 
      and P<0.01). The STR was significantly improved in RIC patients than in control 
      subjects (P<0.001). LVEF is also improved 7 days after myocardial infarction 
      (P=0.001). However, LVEF was not significantly different between study groups 
      over 1 month (P=0.65). CONCLUSIONS: There may be a cardioprotective effect of RIC 
      before, during, or after reperfusion, in the setting of acute STEMI.
FAU - Gao, Jing
AU  - Gao J
AD  - Department of Cardiology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
AD  - Department of Endocrinology, Fifth Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
FAU - Chen, Qingjie
AU  - Chen Q
AD  - Department of Cardiology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
FAU - Liu, Fen
AU  - Liu F
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
FAU - Zhao, Qian
AU  - Zhao Q
AD  - Department of Cardiology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
FAU - Chen, Bangdang
AU  - Chen B
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
FAU - Zhou, Yun
AU  - Zhou Y
AD  - Department of Cardiology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
FAU - Zhao, Qiang
AU  - Zhao Q
AD  - Department of Cardiology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
FAU - Ma, Yitong
AU  - Ma Y
AD  - Department of Cardiology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China.
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
FAU - Yang, Yining
AU  - Yang Y
AD  - Department of Cardiology, First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, China - yangyn5126@163.com.
AD  - Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20170217
PL  - Italy
TA  - Minerva Med
JT  - Minerva medica
JID - 0400732
SB  - IM
MH  - Clinical Trials as Topic
MH  - Humans
MH  - *Ischemic Preconditioning, Myocardial
MH  - Myocardial Reperfusion Injury/*prevention & control
MH  - *Percutaneous Coronary Intervention/adverse effects/methods
MH  - ST Elevation Myocardial Infarction/blood/diagnosis/physiopathology/*therapy
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2017/02/22 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/02/21 06:00
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
PHST- 2017/02/21 06:00 [entrez]
AID - S0026-4806.17.04631-6 [pii]
AID - 10.23736/S0026-4806.17.04631-6 [doi]
PST - ppublish
SO  - Minerva Med. 2017 Aug;108(4):370-380. doi: 10.23736/S0026-4806.17.04631-6. Epub 
      2017 Feb 17.