PMID- 28218201
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 2303-9027 (Print)
IS  - 2226-7190 (Electronic)
IS  - 2226-7190 (Linking)
VI  - 6
IP  - 1
DP  - 2017 Jan-Feb
TI  - B-mode and contrast-enhancement characteristics of small nonincidental 
      neuroendocrine pancreatic tumors.
PG  - 49-54
LID - 10.4103/2303-9027.200213 [doi]
AB  - BACKGROUND AND OBJECTIVES: Imaging of the pancreas for detection of 
      neuroendocrine tumors is indicated as surveillance in multiple endocrine 
      neoplasia type 1 (MEN1) or if typical clinical symptoms combined with hormone 
      production raise the suspicion of a neuroendocrine tumor. Endoscopic ultrasound 
      (EUS) is considered the best imaging modality to detect small pancreatic tumors. 
      However, little is known about how small pancreatic neuroendocrine tumors (pNETs) 
      present on EUS. PATIENTS AND METHODS: In this multicenter study, we 
      retrospectively analyzed the endosonographic characteristics of small pNETs which 
      had been detected due to typical biochemistry and clinical symptoms or during 
      surveillance of MEN 1. Only small pancreatic tumors </=15 mm with histological 
      confirmation as pNET were included. B-mode and contrast-enhanced ultrasound- and 
      EUS patterns were analyzed. RESULTS: Among 32 patients with histologically proven 
      small pNETs, 7 patients had known MEN1. Among the pNETs, 20 were insulinoma, 2 
      gastrinoma, 3 glucagonoma, 6 nonfunctional in MEN1, and one PPoma. 94% of the 
      pNET appeared hypoechogenic, only 1 isoechogenic and 1 hyperechogenic. After 
      contrast injection, 90% of the pNETS showed hyperenhancement compared to the 
      surrounding pancreatic parenchyma. CONCLUSION: The high spatial resolution of EUS 
      allows detection and even cytological confirmation of pNET <7 mm diameter. 
      Hypoechogenicity in B-mode and hyperenhancement after injection of contrast 
      agents are endosonographic characteristics of small pNET and present in >90% of 
      pNETs.
FAU - Braden, Barbara
AU  - Braden B
AD  - Translational Gastroenterology Unit, Oxford University Hospitals, Oxford, UK.
FAU - Jenssen, Christian
AU  - Jenssen C
AD  - Medical Department, Krankenhaus Maerkisch-Oderland, Strausberg, Germany.
FAU - D'Onofrio, Mirko
AU  - D'Onofrio M
AD  - Department of Radiology, G.B. Rossi University Hospital, University of Verona, 
      Verona, Italy.
FAU - Hocke, Michael
AU  - Hocke M
AD  - Medical Department, Helios Klinikum Meiningen, Meiningen, Germany.
FAU - Will, Uwe
AU  - Will U
AD  - SRH Wald-Klinikum Gera, Gera, Germany.
FAU - Moller, Kathleen
AU  - Moller K
AD  - Medical Department I/Gastroenterology, Sana Hospital Lichtenberg, Berlin, 
      Germany.
FAU - Ignee, Andre
AU  - Ignee A
AD  - Medical Department, Caritas-Krankenhaus, Uhlandstr. 7 D-97980 Bad Mergentheim, 
      Germany.
FAU - Dong, Yi
AU  - Dong Y
AD  - Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Cui, Xin-Wu
AU  - Cui XW
AD  - Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Saftoiu, Adrian
AU  - Saftoiu A
AD  - Department of Gastroenterology, Research Center of Gastroenterology and 
      Hepatology, University of Medicine and Pharmacy Craiova, Craiova, Romania.
FAU - Dietrich, Christoph F
AU  - Dietrich CF
AD  - Medical Department, Caritas-Krankenhaus, Uhlandstr. 7 D-97980 Bad Mergentheim, 
      Germany; Sino-German Research Center of Ultrasound in Medicine, The first 
      Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Endosc Ultrasound
JT  - Endoscopic ultrasound
JID - 101622292
PMC - PMC5331844
COIS- There are no conflicts of interest.
EDAT- 2017/02/22 06:00
MHDA- 2017/02/22 06:01
PMCR- 2017/01/01
CRDT- 2017/02/21 06:00
PHST- 2017/02/21 06:00 [entrez]
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2017/02/22 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - EndoscUltrasound_2017_6_1_49_200213 [pii]
AID - EUS-6-49 [pii]
AID - 10.4103/2303-9027.200213 [doi]
PST - ppublish
SO  - Endosc Ultrasound. 2017 Jan-Feb;6(1):49-54. doi: 10.4103/2303-9027.200213.