PMID- 28218451
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20230120
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 61
IP  - 8
DP  - 2017 Aug
TI  - Specific inulin-type fructan fibers protect against autoimmune diabetes by 
      modulating gut immunity, barrier function, and microbiota homeostasis.
LID - 10.1002/mnfr.201601006 [doi]
AB  - SCOPE: Dietary fibers capable of modifying gut barrier and microbiota homeostasis 
      affect the progression of type 1 diabetes (T1D). Here, we aim to compare 
      modulatory effects of inulin-type fructans (ITFs), natural soluble dietary fibers 
      with different degrees of fermentability from chicory root, on T1D development in 
      nonobese diabetic mice. METHODS AND RESULTS: Female nonobese diabetic mice were 
      weaned to long- and short-chain ITFs [ITF(l) and ITF(s), 5%] supplemented diet up 
      to 24 weeks. T1D incidence, pancreatic-gut immune responses, gut barrier 
      function, and microbiota composition were analyzed. ITF(l) but not ITF(s) 
      supplementation dampened the incidence of T1D. ITF(l) promoted modulatory T-cell 
      responses, as evidenced by increased CD25(+) Foxp3(+) CD4(+) regulatory T cells, 
      decreased IL17A(+) CD4(+) Th17 cells, and modulated cytokine production profile 
      in the pancreas, spleen, and colon. Furthermore, ITF(l) suppressed NOD like 
      receptor protein 3 caspase-1-p20-IL-1beta inflammasome in the colon. Expression of 
      barrier reinforcing tight junction proteins occludin and claudin-2, antimicrobial 
      peptides beta-defensin-1, and cathelicidin-related antimicrobial peptide as well as 
      short-chain fatty acid production were enhanced by ITF(l). Next-generation 
      sequencing analysis revealed that ITF(l) enhanced Firmicutes/Bacteroidetes ratio 
      to an antidiabetogenic balance and enriched modulatory Ruminococcaceae and 
      Lactobacilli. CONCLUSION: Our data demonstrate that ITF(l) but not ITF(s) delays 
      the development of T1D via modulation of gut-pancreatic immunity, barrier 
      function, and microbiota homeostasis.
CI  - (c) 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Chen, Kang
AU  - Chen K
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, P. R. China.
FAU - Chen, Hao
AU  - Chen H
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, P. R. China.
FAU - Faas, Marijke M
AU  - Faas MM
AD  - Immunoendocrinology, Division of Medical Biology, Department of Pathology and 
      Medical Biology, University of Groningen, University Medical Center Groningen, 
      Groningen, The Netherlands.
FAU - de Haan, Bart J
AU  - de Haan BJ
AD  - Immunoendocrinology, Division of Medical Biology, Department of Pathology and 
      Medical Biology, University of Groningen, University Medical Center Groningen, 
      Groningen, The Netherlands.
FAU - Li, Jiahong
AU  - Li J
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, P. R. China.
FAU - Xiao, Ping
AU  - Xiao P
AD  - Institute of Clinical Medical Research, Affiliated Foshan Hospital of Sun Yat-sen 
      University, Foshan, P.R. China.
FAU - Zhang, Hao
AU  - Zhang H
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, P. R. China.
FAU - Diana, Julien
AU  - Diana J
AD  - Sorbonne Paris Cite, Universite Paris Descartes, Paris, France.
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), Unite 1151, 
      Institut Necker-Enfants Malades (INEM), Centre National de la Recherche 
      ITF(l)enctifique, Paris, France.
FAU - de Vos, Paul
AU  - de Vos P
AD  - Immunoendocrinology, Division of Medical Biology, Department of Pathology and 
      Medical Biology, University of Groningen, University Medical Center Groningen, 
      Groningen, The Netherlands.
FAU - Sun, Jia
AU  - Sun J
AD  - State Key Laboratory of Food Science and Technology, School of Food Science and 
      Technology, Jiangnan University, Wuxi, P. R. China.
AD  - School of Medicine, Jiangnan University, Wuxi, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170324
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
RN  - 0 (Cytokines)
RN  - 0 (Dietary Fiber)
RN  - 0 (Fructans)
RN  - 9005-80-5 (Inulin)
SB  - IM
MH  - Animals
MH  - Colon/cytology/drug effects/immunology
MH  - Cytokines/metabolism
MH  - Diabetes Mellitus, Type 1/microbiology/*prevention & control
MH  - Dietary Fiber/*pharmacology
MH  - Female
MH  - Fructans/chemistry/immunology/*pharmacology
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Inulin/chemistry/pharmacology
MH  - Mice, Inbred NOD
MH  - Pancreas/cytology/drug effects/immunology
MH  - Spleen/cytology/drug effects/immunology
MH  - Th17 Cells/drug effects
OTO - NOTNLM
OT  - Barrier integrity
OT  - Dietary fibers
OT  - Gastroentero pancreatic regulation
OT  - Gut microbiota homeostasis
OT  - Immunomodulation
OT  - Nutritional intervention
OT  - Pancreatic-gut immunity
OT  - Type 1 diabetes pathophysiology
EDAT- 2017/02/22 06:00
MHDA- 2018/05/23 06:00
CRDT- 2017/02/21 06:00
PHST- 2016/11/17 00:00 [received]
PHST- 2017/01/07 00:00 [revised]
PHST- 2017/02/02 00:00 [accepted]
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/02/21 06:00 [entrez]
AID - 10.1002/mnfr.201601006 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201601006. Epub 2017 Mar 24.