PMID- 28218562
OWN - NLM
STAT- MEDLINE
DCOM- 20170619
LR  - 20170619
IS  - 0301-1526 (Print)
IS  - 0301-1526 (Linking)
VI  - 46
IP  - 3
DP  - 2017 May
TI  - C-reactive protein as a marker of progression of carotid atherosclerosis in 
      subjects with type 2 diabetes mellitus.
PG  - 187-192
LID - 10.1024/0301-1526/a000614 [doi]
AB  - BACKGROUND: This prospective study was designed to evaluate the effect of 
      inflammatory markers on the presence and progression of subclinical markers of 
      carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 
      diabetes mellitus (T2DM). PATIENTS AND METHODS: A total of 595 subjects with T2DM 
      were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima 
      media thickness (CIMT), plaque thickness, and plaques presence) were assessed 
      with ultrasound at the time of recruitment and again after 3.8 years. Subjects 
      with T2DM were divided into 2 groups according to the plasma high sensitive 
      C-reactive protein (hs-CRP) levels (subjects with hs-CRP >/= 2 mg/L and subjects 
      with hs-CRP below 2 mg/L). RESULTS: Subjects with T2DM and hs-CRP levels >/= 2 mg/L 
      had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 
      mg/L, and higher incidence of plaques/unstable plaques in comparison with 
      subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic 
      regression analysis found the association between the HDL cholesterol level and 
      presence of plaques, whereas the inflammatory marker hs-CRP was not associated 
      with subclinical markers of progression of carotid atherosclerosis. Multiple 
      linear regression analysis found the association between the hs-CRP levels and 
      either CIMT progression rate or a change in the number of sites with plaques in a 
      3.8-year follow-up. CONCLUSIONS: We demonstrated an association between the 
      inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable 
      plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found 
      the association between hs-CRP levels and either CIMT progression rate or a 
      change in the number of sites with plaques in a 3.8-year follow-up in subjects 
      with T2DM.
FAU - Pleskovic, Ales
AU  - Pleskovic A
AD  - 1 Department of Cardiology, University Medical Centre Ljubljana, Ljubljana, 
      Slovenia.
FAU - Letonja, Marija Santl
AU  - Letonja MS
AD  - 2 General Hospital Rakican, Murska Sobota, Slovenia.
FAU - Vujkovac, Andreja Cokan
AU  - Vujkovac AC
AD  - 3 General Hospital Slovenj Gradec, Slovenj Gradec, Slovenia.
FAU - Nikolajevic Starcevic, Jovana
AU  - Nikolajevic Starcevic J
AD  - 4 Institute of Histology and Embryology, Faculty of Medicine, University of 
      Ljubljana, Ljubljana, Slovenia.
AD  - 5 University Medical Centre Ljubljana, Ljubljana, Slovenia.
FAU - Gazdikova, Katarina
AU  - Gazdikova K
AD  - 6 Department of Nutrition, Faculty of Nursing and Professional Health Studies, 
      Slovak Medical University, Bratislava, Slovak Republic.
AD  - 7 Department of General Medicine, Faculty of Medicine, Slovak Medical University, 
      Bratislava, Slovak Republic.
FAU - Caprnda, Martin
AU  - Caprnda M
AD  - 8 2. Department of Internal Medicine, Faculty of Medicine, Comenius University, 
      Bratislava, Slovak Republic.
FAU - Gaspar, Ludovit
AU  - Gaspar L
AD  - 8 2. Department of Internal Medicine, Faculty of Medicine, Comenius University, 
      Bratislava, Slovak Republic.
FAU - Kruzliak, Peter
AU  - Kruzliak P
AD  - 9 Research and Development Services, Brno, Czech Republic.
AD  - 10 Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary 
      and Pharmaceutical Sciences, Brno, Czech Republic.
AD  - 11 2. Department of Surgery, Faculty of Medicine, Masaryk University and St. 
      Anne's University Hospital, Brno, Czech Republic.
FAU - Petrovic, Danijel
AU  - Petrovic D
AD  - 4 Institute of Histology and Embryology, Faculty of Medicine, University of 
      Ljubljana, Ljubljana, Slovenia.
AD  - 5 University Medical Centre Ljubljana, Ljubljana, Slovenia.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20170220
PL  - Switzerland
TA  - Vasa
JT  - VASA. Zeitschrift fur Gefasskrankheiten
JID - 0317051
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Inflammation Mediators)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Carotid Artery Diseases/*blood/diagnosis/epidemiology
MH  - Carotid Intima-Media Thickness
MH  - Chi-Square Distribution
MH  - Cholesterol, HDL/blood
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/epidemiology
MH  - Diabetic Angiopathies/*blood/diagnosis/epidemiology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Inflammation Mediators/*blood
MH  - Linear Models
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Plaque, Atherosclerotic
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Risk Factors
MH  - Slovenia/epidemiology
MH  - Time Factors
OTO - NOTNLM
OT  - Carotid atherosclerosis
OT  - high sensitive C-reactive protein
OT  - inflammation
OT  - prospective study
EDAT- 2017/02/22 06:00
MHDA- 2017/06/20 06:00
CRDT- 2017/02/21 06:00
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2017/06/20 06:00 [medline]
PHST- 2017/02/21 06:00 [entrez]
AID - 10.1024/0301-1526/a000614 [doi]
PST - ppublish
SO  - Vasa. 2017 May;46(3):187-192. doi: 10.1024/0301-1526/a000614. Epub 2017 Feb 20.