PMID- 28218579
OWN - NLM
STAT- MEDLINE
DCOM- 20171207
LR  - 20221207
IS  - 1488-2353 (Electronic)
IS  - 0147-958X (Linking)
VI  - 40
IP  - 1
DP  - 2017 Feb 19
TI  - Effect of obstructive sleep apnea on carotid artery intima media thickness 
      related to inflammation.
PG  - E25-E33
AB  - PURPOSE: Obstructive sleep apnea hypopnea syndrome (OSAHS) is an independent risk 
      factor for atherosclerosis. To ascertain the effect of OSAHS on the development 
      of atherosclerosis in Chinese OSAHS patients, we evaluated markers of 
      atherosclerosis as well as vascular endothelial function and inflammation. 
      METHODS: Chinese men with polysomnography-diagnosed OSAHS were subgrouped into 
      mild-moderate (n = 28) and severe (n = 54) OSAHS groups on the basis of apnea 
      hypopnea index (AHI) scores. The control group was made up of 30 healthy men. 
      Atherosclerosis was assessed by carotid artery intima-media thickness (IMT) of 
      both sides, flow-mediated dilation (FMD), and inflammation by interleukin-6 
      (IL-6), high-sensitivity C-reactive protein (hs-CRP), vascular endothelial growth 
      factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) levels. RESULTS: 
      Linear regression analysis was used to identify significant associations among 
      risk factors and carotid IMT. The following parameters were significantly higher 
      in patients with severe OSAHS than in the control group: waking triglycerides, 
      total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, blood 
      uric acid, blood glucose, IL-6 and hs-CRP. FMD in severe OSAHS patients was lower 
      than in the control group. AHI score, waking hs-CRP, waking oxidized low-density 
      lipoprotein, blood glucose, and vascular endothelial growth factor (VEGF) level 
      were positively associated with IMT. CONCLUSIONS: In Chinese male patients with 
      severe OSAHS, the significantly higher carotid IMT and levels of inflammatory 
      factors (IL-6 and hs-CRP) and lower FMD suggest that arterial endothelial damage 
      and inflammation may play important roles in the development of atherosclerosis 
      in OSAHS patients.
FAU - Kong, Delei
AU  - Kong D
AD  - Department of Respiratory Disease, First Affiliated Hospital of China Medical 
      University, Shenyang 110001, China. email@email.com.
FAU - Qin, Zheng
AU  - Qin Z
FAU - Wang, Wei
AU  - Wang W
FAU - Kang, Jian
AU  - Kang J
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170219
PL  - Canada
TA  - Clin Invest Med
JT  - Clinical and investigative medicine. Medecine clinique et experimentale
JID - 7804071
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Atherosclerosis/blood/diagnostic imaging/etiology
MH  - C-Reactive Protein/*metabolism
MH  - *Carotid Intima-Media Thickness
MH  - Chemokine CCL2/*blood
MH  - China
MH  - Humans
MH  - Inflammation
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - *Sleep Apnea, Obstructive/blood/complications/diagnostic imaging
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2017/02/22 06:00
MHDA- 2017/12/08 06:00
CRDT- 2017/02/21 06:00
PHST- 2017/02/19 00:00 [received]
PHST- 2017/02/21 06:00 [entrez]
PHST- 2017/02/22 06:00 [pubmed]
PHST- 2017/12/08 06:00 [medline]
AID - 10.25011/cim.v40i1.28051 [doi]
PST - epublish
SO  - Clin Invest Med. 2017 Feb 19;40(1):E25-E33. doi: 10.25011/cim.v40i1.28051.